Role of Tamm-Horsfall protein in the binding and in vivo phagocytosis of type 1 fimbriated Escherichia coli by mouse peritoneal macrophages

Tamm-Horsfall glycoprotein (THP) contains manno-oligosaccharides that are recognized by type 1 fimbriae (F1) of Escherichia coli. In the present study, we examined the in vivo phagocytic activity of mouse peritoneal macrophages after treatment of bacteria with THP. At low THP concentrations (12.5 µg...

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Main Authors:	A.C.S.C. Bastos, L.B. Santos, W.M.S.C. Tamashiro, A.T. Yamada, U.M. Oliveira, T. Yano
Format:	Article
Language:	English
Published:	Associação Brasileira de Divulgação Científica 2001-07-01
Series:	Brazilian Journal of Medical and Biological Research
Subjects:	Tamm-Horsfall protein type 1 fimbriated E. coli phagocytosis
Online Access:	http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2001000700011

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spelling	doaj-06856872db05463cbb11eed04ade69232020-11-24T23:45:00ZengAssociação Brasileira de Divulgação CientíficaBrazilian Journal of Medical and Biological Research0100-879X1414-431X2001-07-0134791391710.1590/S0100-879X2001000700011Role of Tamm-Horsfall protein in the binding and in vivo phagocytosis of type 1 fimbriated Escherichia coli by mouse peritoneal macrophagesA.C.S.C. BastosL.B. SantosW.M.S.C. TamashiroA.T. YamadaU.M. OliveiraT. YanoTamm-Horsfall glycoprotein (THP) contains manno-oligosaccharides that are recognized by type 1 fimbriae (F1) of Escherichia coli. In the present study, we examined the in vivo phagocytic activity of mouse peritoneal macrophages after treatment of bacteria with THP. At low THP concentrations (12.5 µg/ml and 50 µg/ml) no significant difference was observed in the phagocytosis of E. coli F1+. However, at high THP concentrations (500 µg/ml and 1250 µg/ml) we obtained a reduction of bacterial phagocytosis by mouse peritoneal macrophages.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2001000700011Tamm-Horsfall proteintype 1 fimbriated E. coliphagocytosis
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	A.C.S.C. Bastos L.B. Santos W.M.S.C. Tamashiro A.T. Yamada U.M. Oliveira T. Yano
spellingShingle	A.C.S.C. Bastos L.B. Santos W.M.S.C. Tamashiro A.T. Yamada U.M. Oliveira T. Yano Role of Tamm-Horsfall protein in the binding and in vivo phagocytosis of type 1 fimbriated Escherichia coli by mouse peritoneal macrophages Brazilian Journal of Medical and Biological Research Tamm-Horsfall protein type 1 fimbriated E. coli phagocytosis
author_facet	A.C.S.C. Bastos L.B. Santos W.M.S.C. Tamashiro A.T. Yamada U.M. Oliveira T. Yano
author_sort	A.C.S.C. Bastos
title	Role of Tamm-Horsfall protein in the binding and in vivo phagocytosis of type 1 fimbriated Escherichia coli by mouse peritoneal macrophages
title_short	Role of Tamm-Horsfall protein in the binding and in vivo phagocytosis of type 1 fimbriated Escherichia coli by mouse peritoneal macrophages
title_full	Role of Tamm-Horsfall protein in the binding and in vivo phagocytosis of type 1 fimbriated Escherichia coli by mouse peritoneal macrophages
title_fullStr	Role of Tamm-Horsfall protein in the binding and in vivo phagocytosis of type 1 fimbriated Escherichia coli by mouse peritoneal macrophages
title_full_unstemmed	Role of Tamm-Horsfall protein in the binding and in vivo phagocytosis of type 1 fimbriated Escherichia coli by mouse peritoneal macrophages
title_sort	role of tamm-horsfall protein in the binding and in vivo phagocytosis of type 1 fimbriated escherichia coli by mouse peritoneal macrophages
publisher	Associação Brasileira de Divulgação Científica
series	Brazilian Journal of Medical and Biological Research
issn	0100-879X 1414-431X
publishDate	2001-07-01
description	Tamm-Horsfall glycoprotein (THP) contains manno-oligosaccharides that are recognized by type 1 fimbriae (F1) of Escherichia coli. In the present study, we examined the in vivo phagocytic activity of mouse peritoneal macrophages after treatment of bacteria with THP. At low THP concentrations (12.5 µg/ml and 50 µg/ml) no significant difference was observed in the phagocytosis of E. coli F1+. However, at high THP concentrations (500 µg/ml and 1250 µg/ml) we obtained a reduction of bacterial phagocytosis by mouse peritoneal macrophages.
topic	Tamm-Horsfall protein type 1 fimbriated E. coli phagocytosis
url	http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2001000700011
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Role of Tamm-Horsfall protein in the binding and in vivo phagocytosis of type 1 fimbriated Escherichia coli by mouse peritoneal macrophages

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