Role of Tamm-Horsfall protein in the binding and in vivo phagocytosis of type 1 fimbriated Escherichia coli by mouse peritoneal macrophages

Role of Tamm-Horsfall protein in the binding and in vivo phagocytosis of type 1 fimbriated Escherichia coli by mouse peritoneal macrophages

Tamm-Horsfall glycoprotein (THP) contains manno-oligosaccharides that are recognized by type 1 fimbriae (F1) of Escherichia coli. In the present study, we examined the in vivo phagocytic activity of mouse peritoneal macrophages after treatment of bacteria with THP. At low THP concentrations (12.5 µg...

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Bibliographic Details
Main Authors: A.C.S.C. Bastos, L.B. Santos, W.M.S.C. Tamashiro, A.T. Yamada, U.M. Oliveira, T. Yano
Format: Article
Language:English
Published: Associação Brasileira de Divulgação Científica 2001-07-01
Series:Brazilian Journal of Medical and Biological Research
Subjects:
Tamm-Horsfall protein
type 1 fimbriated E. coli
phagocytosis
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2001000700011
Description
Summary:Tamm-Horsfall glycoprotein (THP) contains manno-oligosaccharides that are recognized by type 1 fimbriae (F1) of Escherichia coli. In the present study, we examined the in vivo phagocytic activity of mouse peritoneal macrophages after treatment of bacteria with THP. At low THP concentrations (12.5 µg/ml and 50 µg/ml) no significant difference was observed in the phagocytosis of E. coli F1+. However, at high THP concentrations (500 µg/ml and 1250 µg/ml) we obtained a reduction of bacterial phagocytosis by mouse peritoneal macrophages.
ISSN:0100-879X
1414-431X

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