ISCA1 is essential for mitochondrial Fe4S4 biogenesis in vivo

ISCA1 is essential for mitochondrial Fe4S4 biogenesis in vivo

The mitochondrial proteins ISCA1 and ISCA2 form a complex that is involved in the biogenesis of Fe–S clusters. Here the authors report that ISCA1 and ISCA2 interact differently with proteins of the Fe–S machinery and that under certain conditions, ISCA2 seems dispensable for Fe–S biogenesis.

Bibliographic Details
Main Authors: Lena Kristina Beilschmidt, Sandrine Ollagnier de Choudens, Marjorie Fournier, Ioannis Sanakis, Marc-André Hograindleur, Martin Clémancey, Geneviève Blondin, Stéphane Schmucker, Aurélie Eisenmann, Amélie Weiss, Pascale Koebel, Nadia Messaddeq, Hélène Puccio, Alain Martelli
Format: Article
Language:English
Published: Nature Publishing Group 2017-05-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/ncomms15124
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spelling doaj-067e79be2eb44b3496a3b8fba496a36b2021-05-11T07:31:11ZengNature Publishing GroupNature Communications2041-17232017-05-018111210.1038/ncomms15124ISCA1 is essential for mitochondrial Fe4S4 biogenesis in vivoLena Kristina Beilschmidt0Sandrine Ollagnier de Choudens1Marjorie Fournier2Ioannis Sanakis3Marc-André Hograindleur4Martin Clémancey5Geneviève Blondin6Stéphane Schmucker7Aurélie Eisenmann8Amélie Weiss9Pascale Koebel10Nadia Messaddeq11Hélène Puccio12Alain Martelli13IGBMC (Institut de Génétique et de Biologie Moléculaire et Cellulaire) Translational Medicine and Neurogenetics DepartmentCEA/DRF/BIG/CBM/BioCatIGBMC (Institut de Génétique et de Biologie Moléculaire et Cellulaire) Translational Medicine and Neurogenetics DepartmentNCSR, Demokritos, Institut of Materials ScienceCEA/DRF/BIG/CBM/BioCatCNRS UMR 5249, LCBMCNRS UMR 5249, LCBMIGBMC (Institut de Génétique et de Biologie Moléculaire et Cellulaire) Translational Medicine and Neurogenetics DepartmentIGBMC (Institut de Génétique et de Biologie Moléculaire et Cellulaire) Translational Medicine and Neurogenetics DepartmentIGBMC (Institut de Génétique et de Biologie Moléculaire et Cellulaire) Translational Medicine and Neurogenetics DepartmentIGBMC (Institut de Génétique et de Biologie Moléculaire et Cellulaire) Translational Medicine and Neurogenetics DepartmentIGBMC (Institut de Génétique et de Biologie Moléculaire et Cellulaire) Translational Medicine and Neurogenetics DepartmentIGBMC (Institut de Génétique et de Biologie Moléculaire et Cellulaire) Translational Medicine and Neurogenetics DepartmentIGBMC (Institut de Génétique et de Biologie Moléculaire et Cellulaire) Translational Medicine and Neurogenetics DepartmentThe mitochondrial proteins ISCA1 and ISCA2 form a complex that is involved in the biogenesis of Fe–S clusters. Here the authors report that ISCA1 and ISCA2 interact differently with proteins of the Fe–S machinery and that under certain conditions, ISCA2 seems dispensable for Fe–S biogenesis.https://doi.org/10.1038/ncomms15124
collection DOAJ
language English
format Article
sources DOAJ
author Lena Kristina Beilschmidt
Sandrine Ollagnier de Choudens
Marjorie Fournier
Ioannis Sanakis
Marc-André Hograindleur
Martin Clémancey
Geneviève Blondin
Stéphane Schmucker
Aurélie Eisenmann
Amélie Weiss
Pascale Koebel
Nadia Messaddeq
Hélène Puccio
Alain Martelli
spellingShingle Lena Kristina Beilschmidt
Sandrine Ollagnier de Choudens
Marjorie Fournier
Ioannis Sanakis
Marc-André Hograindleur
Martin Clémancey
Geneviève Blondin
Stéphane Schmucker
Aurélie Eisenmann
Amélie Weiss
Pascale Koebel
Nadia Messaddeq
Hélène Puccio
Alain Martelli
ISCA1 is essential for mitochondrial Fe4S4 biogenesis in vivo
Nature Communications
author_facet Lena Kristina Beilschmidt
Sandrine Ollagnier de Choudens
Marjorie Fournier
Ioannis Sanakis
Marc-André Hograindleur
Martin Clémancey
Geneviève Blondin
Stéphane Schmucker
Aurélie Eisenmann
Amélie Weiss
Pascale Koebel
Nadia Messaddeq
Hélène Puccio
Alain Martelli
author_sort Lena Kristina Beilschmidt
title ISCA1 is essential for mitochondrial Fe4S4 biogenesis in vivo
title_short ISCA1 is essential for mitochondrial Fe4S4 biogenesis in vivo
title_full ISCA1 is essential for mitochondrial Fe4S4 biogenesis in vivo
title_fullStr ISCA1 is essential for mitochondrial Fe4S4 biogenesis in vivo
title_full_unstemmed ISCA1 is essential for mitochondrial Fe4S4 biogenesis in vivo
title_sort isca1 is essential for mitochondrial fe4s4 biogenesis in vivo
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2017-05-01
description The mitochondrial proteins ISCA1 and ISCA2 form a complex that is involved in the biogenesis of Fe–S clusters. Here the authors report that ISCA1 and ISCA2 interact differently with proteins of the Fe–S machinery and that under certain conditions, ISCA2 seems dispensable for Fe–S biogenesis.
url https://doi.org/10.1038/ncomms15124
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