Uncoupling protein 2 regulates daily rhythms of insulin secretion capacity in MIN6 cells and isolated islets from male mice

Uncoupling protein 2 regulates daily rhythms of insulin secretion capacity in MIN6 cells and isolated islets from male mice

Objective: Upregulation of uncoupling protein 2 (UCP2) is associated with impaired glucose-stimulated insulin secretion (GSIS), which is thought to be an important contributor to pathological β cell failure in obesity and type 2 diabetes (T2D); however, the physiological function of UCP2 in the β ce...

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Bibliographic Details
Main Authors: Nivedita Seshadri, Michael E. Jonasson, Kristin L. Hunt, Bo Xiang, Steven Cooper, Michael B. Wheeler, Vernon W. Dolinsky, Christine A. Doucette
Format: Article
Language:English
Published: Elsevier 2017-07-01
Series:Molecular Metabolism
Subjects:
Uncoupling protein 2
Glucose-stimulated insulin secretion
Glucose tolerance
Pancreatic islets
β cells
Online Access:http://www.sciencedirect.com/science/article/pii/S2212877817301072

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