Relationship between <it>cyclooxygenase 8473T>C </it>polymorphism and the risk of lung cancer: a case-control study

• Main Authors: Kang Young, Kam Sin, Kim Chang, Son Ji-Woong, Cha Sung, Lee Won, Chae Myung, Choi Jin, Park Jung, Jung Tae, Park Jae
• Format: Article
• Language: English
• Published: BMC 2006-03-01
• Series: BMC Cancer
• Online Access: http://www.biomedcentral.com/1471-2407/6/70

<p>Abstract</p> <p>Background</p> <p>Cyclooxygenase-2 (COX-2) plays an important role in the development of lung cancer. DNA sequence variations in the <it>COX-2 </it>gene may lead to altered COX-2 production and/or activity, and so they cause inter-individual differences in the susceptibility to lung cancer. To test this hypothesis, we investigated the association between the <it>8473T>C </it>polymorphism in the 3'-untranslated region of the <it>COX-2 </it>gene and the risk of lung cancer in a Korean population.</p> <p>Methods</p> <p>The <it>COX-2 </it>genotypes were determined using PCR-based primer-introduced restriction analysis in 582 lung cancer patients and in 582 healthy controls that were frequency-matched for age and gender.</p> <p>Results</p> <p>The distribution of the <it>COX-2 8473T>C </it>genotypes was not significantly different between the overall lung cancer cases and the controls. However, when the cases were categorized by the tumor histology, the combined <it>8473 TC </it>+ <it>CC </it>genotype was associated with a significantly decreased risk of adenocarcinoma as compared with the <it>8473 TT </it>genotype (adjusted OR = 0.64; 95% CI = 0.46–0.90, <it>P </it>= 0.01). On the stratification analysis, the protective effect of the combined <it>8473 TC </it>+ <it>CC </it>genotype against adenocarcinoma was statistically significant in the males, older individuals and ever-smokers (adjusted OR = 0.59; 95% CI = 0.39–0.91, <it>P </it>= 0.02; adjusted OR = 0.55; 95% CI = 0.33–0.93, <it>P </it>= 0.03; and adjusted OR = 0.57; 95% CI = 0.37–0.87, <it>P </it>= 0.01, respectively).</p> <p>Conclusion</p> <p>These findings suggest that the <it>COX-2 8473T>C </it>polymorphism could be used as a marker for the genetic susceptibility to adenocarcinoma of the lung.</p>