Cycles of autoubiquitination and deubiquitination regulate the ERAD ubiquitin ligase Hrd1

Cycles of autoubiquitination and deubiquitination regulate the ERAD ubiquitin ligase Hrd1

Misfolded proteins in the lumen of the endoplasmic reticulum (ER) are retrotranslocated into the cytosol and polyubiquitinated before being degraded by the proteasome. The multi-spanning ubiquitin ligase Hrd1 forms the retrotranslocation channel and associates with three other membrane proteins (Hrd...

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Bibliographic Details
Main Authors: Brian G Peterson, Morgan L Glaser, Tom A Rapoport, Ryan D Baldridge
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2019-11-01
Series:eLife
Subjects:
ERAD
protein quality control
regulation
protein degradation
Online Access:https://elifesciences.org/articles/50903

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