Polymorphism: the influence on the quality of drugs and actual methods of analysis

• Main Author: G. N. Gildeeva
• Format: Article
• Language: Russian
• Published: Izdatelstvo OKI 2018-05-01
• Series: Качественная клиническая практика
• Subjects: полиморфизм; полиморфные модификации; активная фармацевтическая субстанция; кристаллическая структура; кристаллические модификации; polymorphism; polymorphic modifications; active pharmaceutical substance; crystal structure; crystal modifications
• Online Access: https://www.clinvest.ru/jour/article/view/80
• ISSN: 2588-0519; 2618-8473

Polymorphism is a phenomenon of existence of an individual substance in states with different crystalline structure, each of these states is called a polymorphic modification (PM). The possibility of developing new drugs by detecting the biological activity of xenobiotics is considered to be largely exhausted, so recently, along with the search and development of new drugs, the task of improving known drugs, in particular, through the use of medicinal substances (MS) based on a certain PM of the active substance. Such technologies allow improving the properties, ensuring the quality and safety of drugs at a higher level, and also reducing the costs of developing patent-protected drugs, which contributes to the development of the pharmaceutical industry.