Centrosome polarization in T cells: a task for formins

Centrosome polarization in T cells: a task for formins

T-cell antigen receptor (TCR) engagement triggers the rapid reorientation of the centrosome, which is associated with the secretory machinery, towards the immunological synapse (IS) for polarized protein trafficking. Recent evidence indicates that upon TCR triggering the INF2 formin, together with t...

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Bibliographic Details
Main Authors: Laura eAndrés-Delgado, Olga Maria Antón, Miguel Angel Alonso
Format: Article
Language:English
Published: Frontiers Media S.A. 2013-07-01
Series:Frontiers in Immunology
Subjects:
Microtubule-Organizing Center
T cells
Tyrosine phosphorylation
formins
detyrosinated microtubules
centrosome reorientation
Online Access:http://journal.frontiersin.org/Journal/10.3389/fimmu.2013.00191/full

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