Successful Treatment with Crushed Sofosbuvir/Velpatasvir of a Patient with Decompensated Cirrhosis C and Thrombocytopenia
A 36-year-old woman with decompensated liver cirrhosis type C was referred to our hospital to receive antiviral treatment for hepatitis C virus (HCV). She had been diagnosed with intractable epilepsy and cerebral palsy at birth and was managed by central venous nutrition and nasal gastric feeding. A...
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Karger Publishers
2021-08-01
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| Series: | Case Reports in Gastroenterology |
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| Online Access: | https://www.karger.com/Article/FullText/518306 |
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doaj-064e66fd2b334df2a7301919394f0be22021-09-02T15:02:16ZengKarger PublishersCase Reports in Gastroenterology1662-06312021-08-0115272973510.1159/000518306518306Successful Treatment with Crushed Sofosbuvir/Velpatasvir of a Patient with Decompensated Cirrhosis C and ThrombocytopeniaAiko Murayama0Kazuto Tajiri1https://orcid.org/0000-0002-2373-8601Chiharu Kanegane2Jun Murakami3Yuka Hayashi4Ichiro Yasuda5The Third Department of Internal Medicine, Faculty of Medicine, University of Toyama, Toyama, JapanThe Third Department of Internal Medicine, Faculty of Medicine, University of Toyama, Toyama, JapanDepartment of Pediatrics, National Hospital Organization Toyama Hospital, Toyama, JapanDivision of Transfusion Medicine and Cell Therapy, Toyama University Hospital, Toyama, JapanThe Third Department of Internal Medicine, Faculty of Medicine, University of Toyama, Toyama, JapanThe Third Department of Internal Medicine, Faculty of Medicine, University of Toyama, Toyama, JapanA 36-year-old woman with decompensated liver cirrhosis type C was referred to our hospital to receive antiviral treatment for hepatitis C virus (HCV). She had been diagnosed with intractable epilepsy and cerebral palsy at birth and was managed by central venous nutrition and nasal gastric feeding. At age 34 years, she was diagnosed with thrombocytopenia, probably associated with HCV infection. She showed refractory ascites for several months and was therefore administered crushed sofosbuvir/velpatasvir tablets via a nasal gastric tube. Her HCV infection was successfully eradicated, her ascites disappeared, and thrombocytopenia improved with a marked decrease in platelet-associated IgG.https://www.karger.com/Article/FullText/518306decompensated cirrhosis cthrombocytopeniadirect-acting antiviralintractable epilepsycrushed administration |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Aiko Murayama Kazuto Tajiri Chiharu Kanegane Jun Murakami Yuka Hayashi Ichiro Yasuda |
| spellingShingle |
Aiko Murayama Kazuto Tajiri Chiharu Kanegane Jun Murakami Yuka Hayashi Ichiro Yasuda Successful Treatment with Crushed Sofosbuvir/Velpatasvir of a Patient with Decompensated Cirrhosis C and Thrombocytopenia Case Reports in Gastroenterology decompensated cirrhosis c thrombocytopenia direct-acting antiviral intractable epilepsy crushed administration |
| author_facet |
Aiko Murayama Kazuto Tajiri Chiharu Kanegane Jun Murakami Yuka Hayashi Ichiro Yasuda |
| author_sort |
Aiko Murayama |
| title |
Successful Treatment with Crushed Sofosbuvir/Velpatasvir of a Patient with Decompensated Cirrhosis C and Thrombocytopenia |
| title_short |
Successful Treatment with Crushed Sofosbuvir/Velpatasvir of a Patient with Decompensated Cirrhosis C and Thrombocytopenia |
| title_full |
Successful Treatment with Crushed Sofosbuvir/Velpatasvir of a Patient with Decompensated Cirrhosis C and Thrombocytopenia |
| title_fullStr |
Successful Treatment with Crushed Sofosbuvir/Velpatasvir of a Patient with Decompensated Cirrhosis C and Thrombocytopenia |
| title_full_unstemmed |
Successful Treatment with Crushed Sofosbuvir/Velpatasvir of a Patient with Decompensated Cirrhosis C and Thrombocytopenia |
| title_sort |
successful treatment with crushed sofosbuvir/velpatasvir of a patient with decompensated cirrhosis c and thrombocytopenia |
| publisher |
Karger Publishers |
| series |
Case Reports in Gastroenterology |
| issn |
1662-0631 |
| publishDate |
2021-08-01 |
| description |
A 36-year-old woman with decompensated liver cirrhosis type C was referred to our hospital to receive antiviral treatment for hepatitis C virus (HCV). She had been diagnosed with intractable epilepsy and cerebral palsy at birth and was managed by central venous nutrition and nasal gastric feeding. At age 34 years, she was diagnosed with thrombocytopenia, probably associated with HCV infection. She showed refractory ascites for several months and was therefore administered crushed sofosbuvir/velpatasvir tablets via a nasal gastric tube. Her HCV infection was successfully eradicated, her ascites disappeared, and thrombocytopenia improved with a marked decrease in platelet-associated IgG. |
| topic |
decompensated cirrhosis c thrombocytopenia direct-acting antiviral intractable epilepsy crushed administration |
| url |
https://www.karger.com/Article/FullText/518306 |
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