Successful Treatment with Crushed Sofosbuvir/Velpatasvir of a Patient with Decompensated Cirrhosis C and Thrombocytopenia

• Main Authors: Aiko Murayama, Kazuto Tajiri, Chiharu Kanegane, Jun Murakami, Yuka Hayashi, Ichiro Yasuda
• Format: Article
• Language: English
• Published: Karger Publishers 2021-08-01
• Series: Case Reports in Gastroenterology
• Subjects: decompensated cirrhosis c; thrombocytopenia; direct-acting antiviral; intractable epilepsy; crushed administration
• Online Access: https://www.karger.com/Article/FullText/518306
• ISSN: 1662-0631

A 36-year-old woman with decompensated liver cirrhosis type C was referred to our hospital to receive antiviral treatment for hepatitis C virus (HCV). She had been diagnosed with intractable epilepsy and cerebral palsy at birth and was managed by central venous nutrition and nasal gastric feeding. At age 34 years, she was diagnosed with thrombocytopenia, probably associated with HCV infection. She showed refractory ascites for several months and was therefore administered crushed sofosbuvir/velpatasvir tablets via a nasal gastric tube. Her HCV infection was successfully eradicated, her ascites disappeared, and thrombocytopenia improved with a marked decrease in platelet-associated IgG.