Immuno-Expression of Endoglin and Smooth Muscle Actin in the Vessels of Brain Metastases. Is There a Rational for Anti-Angiogenic Therapy?

Immuno-Expression of Endoglin and Smooth Muscle Actin in the Vessels of Brain Metastases. Is There a Rational for Anti-Angiogenic Therapy?

Despite ongoing clinical trials, the efficacy of anti-angiogenic drugs for the treatment of brain metastases (BM) is still questionable. The lower response rate to anti-angiogenic therapy in the presence of BM than in metastatic disease involving other sites suggests that BM may be insensitive to t...

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Bibliographic Details
Main Authors: Valeria Barresi, Giovanni Branca, Maria Caffo, Rosario Caltabiano, Antonio Ieni, Enrica Vitarelli, Salvatore Lanzafame, Giovanni Tuccari
Format: Article
Language:English
Published: MDPI AG 2014-04-01
Series:International Journal of Molecular Sciences
Subjects:
brain metastasis
endoglin
MVD
pericytes
angiogenesis
Online Access:http://www.mdpi.com/1422-0067/15/4/5663

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