Elective neck dissection versus wait-and-see policy in cT1N0 buccal squamous cell carcinoma

• Main Authors: Qigen Fang, Hua Gao, Qing Gao, Jinlan Sun, Peng Li, Meng Cui, Enxi Zhang, Wenlong Yin, Yuanyuan Dong
• Format: Article
• Language: English
• Published: BMC 2020-06-01
• Series: BMC Cancer
• Subjects: Buccal squamous cell carcinoma; Elective neck dissection; Early-stage oral squamous cell carcinoma; Squamous cell carcinoma; Occult lymph node metastasis
• Online Access: http://link.springer.com/article/10.1186/s12885-020-07006-w

Abstract Background Our goal was to clarify the comparison between elective neck dissection (END) and the wait-and-see policy in neck management for cT1N0 buccal squamous cell carcinoma (SCC). Methods This was a retrospective comparison of 175 prospectively enrolled patients with cT1N0 buccal SCC. The patients were divided into two groups based on the nonrandomized management of the neck: 125 patients received END, and 50 patients were exposed to the wait-and-see policy. The main study endpoints were locoregional control (LRC) and disease-specific survival (DSS). Patients were asked to complete the shoulder domain in the University of Washington quality of life questionnaire, version 4, 1 year postoperatively. Results Ten of the patients undergoing END developed recurrence, and the 5-year LRC rate was 92%. Five patients undergoing the wait-and-see policy developed recurrence, and the 5-year LRC rate was 90%. The difference was not significant (p = 0.668). There were 6 deaths in patients undergoing END, and the 5-year DSS rate was 94%. There were 3 deaths in patients undergoing the wait-and-see policy, and the 5-year DSS rate was 94%; the difference was not significant (p = 0.777). The mean shoulder scores of patients undergoing END and the wait-and-see policy were 93.9 and 100, respectively, and the difference was not significant (p = 0.284). Conclusion Elective neck dissection does not carry a survival benefit compared to the wait-and-see policy, and it is not suggested for patients with cT1N0 buccal SCC.