Heterocyclic sterol probes for live monitoring of sterol trafficking and lysosomal storage disorders

Heterocyclic sterol probes for live monitoring of sterol trafficking and lysosomal storage disorders

Abstract The monitoring of intracellular cholesterol homeostasis and trafficking is of great importance because their imbalance leads to many pathologies. Reliable tools for cholesterol detection are in demand. This study presents the design and synthesis of fluorescent probes for cholesterol recogn...

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Bibliographic Details
Main Authors: Jarmila Králová, Michal Jurášek, Lucie Krčová, Bohumil Dolenský, Ivan Novotný, Michal Dušek, Zdeňka Rottnerová, Michal Kahle, Pavel Drašar, Petr Bartůněk, Vladimír Král
Format: Article
Language:English
Published: Nature Publishing Group 2018-09-01
Series:Scientific Reports
Subjects:
Filipin
Cholesterol Trafficking
NPC Fibroblasts
Dehydroergosterol (DHE)
Abiraterone Acetate
Online Access:https://doi.org/10.1038/s41598-018-32776-6

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