Mir-34a mimics are potential therapeutic agents for p53-mutated and chemo-resistant brain tumour cells.

Mir-34a mimics are potential therapeutic agents for p53-mutated and chemo-resistant brain tumour cells.

Chemotherapeutic drug resistance and relapse remains a major challenge for paediatric (medulloblastoma) and adult (glioblastoma) brain tumour treatment. Medulloblastoma tumours and cell lines with mutations in the p53 signalling pathway have been shown to be specifically insensitive to DNA damaging...

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Bibliographic Details
Main Authors: Yuen Ngan Fan, Daniel Meley, Barry Pizer, Violaine Sée
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4177398?pdf=render

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