Preparation of modified polysulfone material decorated by sulfonated citric chitosan for haemodialysis and its haemocompatibility

Polysulfone (PSF) works potentially in haemodialysis due to its great mechanical and chemical stability, but performs poorly in haemocompatibility. For promoting the unpleasant haemocompatibility, sulfonated citric chitosan (SCACS) with the structure and groups similar to heparin was primarily synth...

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Main Authors: Bingxian Lin, Kaiming Liu, Yunren Qiu
Format: Article
Language:English
Published: The Royal Society 2021-09-01
Series:Royal Society Open Science
Subjects:
Online Access:https://royalsocietypublishing.org/doi/10.1098/rsos.210462
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spelling doaj-062ecc5a62d7452b8a6604c9034083e62021-09-08T07:05:42ZengThe Royal SocietyRoyal Society Open Science2054-57032021-09-018910.1098/rsos.210462Preparation of modified polysulfone material decorated by sulfonated citric chitosan for haemodialysis and its haemocompatibilityBingxian Lin0Kaiming Liu1Yunren Qiu2College of Chemistry and Chemical Engineering, Central South University, Changsha 410083, People's Republic of ChinaCollege of Chemistry and Chemical Engineering, Central South University, Changsha 410083, People's Republic of ChinaCollege of Chemistry and Chemical Engineering, Central South University, Changsha 410083, People's Republic of ChinaPolysulfone (PSF) works potentially in haemodialysis due to its great mechanical and chemical stability, but performs poorly in haemocompatibility. For promoting the unpleasant haemocompatibility, sulfonated citric chitosan (SCACS) with the structure and groups similar to heparin was primarily synthesized by acylation and sulfonation. Furthermore, the chloroacylated PSF was pretreated by electrophilic chloroacetyl chloride to achieve more active sites for further reaction; the following membranes underwent the amination and were named amination polysulfone (AMPSF) membranes. Moreover, SCACS with abundant carboxyl and sulfonic groups was covalently grafted at the surface of pretreated PSF membranes, called PSF-SCACS membranes. The PSF-SCACS membranes were successfully synthesized and characterized by 1H NMR, ATR-FTIR and XPS. In addition, the water contact angle of PSF-SCACS membranes decreased by 47° and the morphologies of the membranes changed little compared with the unmodified PSF membranes. The haemocompatible testing results, including protein adsorption, platelet adhesion, haemolysis rate, plasma recalcification time, activated partial thromboplastin time (APTT), prothrombin time (PT) and thrombin time (TT), demonstrated that the PSF-SCACS membranes possessed excellent haemocompatible performances, and SCACS played an important role in the modification.https://royalsocietypublishing.org/doi/10.1098/rsos.210462modified polysulfonesulfonated citric chitosangraft modificationhydrophilicityhaemocompatibility
collection DOAJ
language English
format Article
sources DOAJ
author Bingxian Lin
Kaiming Liu
Yunren Qiu
spellingShingle Bingxian Lin
Kaiming Liu
Yunren Qiu
Preparation of modified polysulfone material decorated by sulfonated citric chitosan for haemodialysis and its haemocompatibility
Royal Society Open Science
modified polysulfone
sulfonated citric chitosan
graft modification
hydrophilicity
haemocompatibility
author_facet Bingxian Lin
Kaiming Liu
Yunren Qiu
author_sort Bingxian Lin
title Preparation of modified polysulfone material decorated by sulfonated citric chitosan for haemodialysis and its haemocompatibility
title_short Preparation of modified polysulfone material decorated by sulfonated citric chitosan for haemodialysis and its haemocompatibility
title_full Preparation of modified polysulfone material decorated by sulfonated citric chitosan for haemodialysis and its haemocompatibility
title_fullStr Preparation of modified polysulfone material decorated by sulfonated citric chitosan for haemodialysis and its haemocompatibility
title_full_unstemmed Preparation of modified polysulfone material decorated by sulfonated citric chitosan for haemodialysis and its haemocompatibility
title_sort preparation of modified polysulfone material decorated by sulfonated citric chitosan for haemodialysis and its haemocompatibility
publisher The Royal Society
series Royal Society Open Science
issn 2054-5703
publishDate 2021-09-01
description Polysulfone (PSF) works potentially in haemodialysis due to its great mechanical and chemical stability, but performs poorly in haemocompatibility. For promoting the unpleasant haemocompatibility, sulfonated citric chitosan (SCACS) with the structure and groups similar to heparin was primarily synthesized by acylation and sulfonation. Furthermore, the chloroacylated PSF was pretreated by electrophilic chloroacetyl chloride to achieve more active sites for further reaction; the following membranes underwent the amination and were named amination polysulfone (AMPSF) membranes. Moreover, SCACS with abundant carboxyl and sulfonic groups was covalently grafted at the surface of pretreated PSF membranes, called PSF-SCACS membranes. The PSF-SCACS membranes were successfully synthesized and characterized by 1H NMR, ATR-FTIR and XPS. In addition, the water contact angle of PSF-SCACS membranes decreased by 47° and the morphologies of the membranes changed little compared with the unmodified PSF membranes. The haemocompatible testing results, including protein adsorption, platelet adhesion, haemolysis rate, plasma recalcification time, activated partial thromboplastin time (APTT), prothrombin time (PT) and thrombin time (TT), demonstrated that the PSF-SCACS membranes possessed excellent haemocompatible performances, and SCACS played an important role in the modification.
topic modified polysulfone
sulfonated citric chitosan
graft modification
hydrophilicity
haemocompatibility
url https://royalsocietypublishing.org/doi/10.1098/rsos.210462
work_keys_str_mv AT bingxianlin preparationofmodifiedpolysulfonematerialdecoratedbysulfonatedcitricchitosanforhaemodialysisanditshaemocompatibility
AT kaimingliu preparationofmodifiedpolysulfonematerialdecoratedbysulfonatedcitricchitosanforhaemodialysisanditshaemocompatibility
AT yunrenqiu preparationofmodifiedpolysulfonematerialdecoratedbysulfonatedcitricchitosanforhaemodialysisanditshaemocompatibility
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