Tissue-Specific Ablation of Prkar1a Causes Schwannomas by Suppressing Neurofibromatosis Protein Production

Tissue-Specific Ablation of Prkar1a Causes Schwannomas by Suppressing Neurofibromatosis Protein Production

Signaling events leading to Schwann cell tumor initiation have been extensively characterized in the context of neurofibromatosis (NF). Similar tumors are also observed in patients with the endocrine neoplasia syndrome Carney complex, which results from inactivating mutations in PRKAR1A. Loss of PR...

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Bibliographic Details
Main Authors: Georgette N. Jones, Chhavy Tep, William H. Towns, II, Georgeta Mihai, Ian D. Tonks, Graham F. Kay, Petra M. Schmalbrock, Anat O. Stemmer-Rachamimov, Sung Ok Yoon, Lawrence S. Kirschner
Format: Article
Language:English
Published: Elsevier 2008-11-01
Series:Neoplasia: An International Journal for Oncology Research
Online Access:http://www.sciencedirect.com/science/article/pii/S1476558608800188

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http://www.sciencedirect.com/science/article/pii/S1476558608800188

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