Targeted Therapy With PI3K and FGFR Inhibitors on Human Papillomavirus Positive and Negative Tonsillar and Base of Tongue Cancer Lines With and Without Corresponding Mutations

Targeted Therapy With PI3K and FGFR Inhibitors on Human Papillomavirus Positive and Negative Tonsillar and Base of Tongue Cancer Lines With and Without Corresponding Mutations

ObjectivesHuman papillomavirus positive (HPV+) tonsillar and base of tongue squamous cell carcinoma (TSCC/BOTSCC), the major subsites of oropharyngeal squamous cell carcinoma (OPSCC) have favorable outcome, but upon relapse, outcome is poor and new therapies needed. Since, phosphatidyl-inositol-4,5-...

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Bibliographic Details
Main Authors: Stefan Holzhauser, Nicole Wild, Mark Zupancic, Ramona G. Ursu, Cinzia Bersani, Anders Näsman, Ourania N. Kostopoulou, Tina Dalianis
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-05-01
Series:Frontiers in Oncology
Subjects:
head neck cancer
HPV
tonsillar cancer
base of tongue cancer
oropharyngeal cancer
FGFR
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2021.640490/full

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https://www.frontiersin.org/articles/10.3389/fonc.2021.640490/full

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