Skeletal Muscle Fibre-Specific Knockout of p53 Does Not Reduce Mitochondrial Content or Enzyme Activity

Skeletal Muscle Fibre-Specific Knockout of p53 Does Not Reduce Mitochondrial Content or Enzyme Activity

Tumour protein 53 (p53) has been implicated in the regulation of mitochondrial biogenesis in skeletal muscle, with whole-body p53 knockout mice displaying impairments in basal mitochondrial content, respiratory capacity, and enzyme activity. This study aimed to determine the effect of skeletal muscl...

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Bibliographic Details
Main Authors: Ben Stocks, Jessica R. Dent, Sophie Joanisse, Carrie E. McCurdy, Andrew Philp
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-12-01
Series:Frontiers in Physiology
Subjects:
p53
skeletal muscle
mitochondria
metabolism
PGC-1α
Online Access:http://journal.frontiersin.org/article/10.3389/fphys.2017.00941/full

Internet

http://journal.frontiersin.org/article/10.3389/fphys.2017.00941/full

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