The Growth of Brown Adipose Tissue in Cold-acclimatized Rats after Depletion of Mast Cell Histamine by Compound 48/80

• Main Authors: Daló Nelson L, López-Ortega Aura A, Moussatché Haity
• Format: Article
• Language: English
• Published: Instituto Oswaldo Cruz, Ministério da Saúde 1998-01-01
• Series: Memórias do Instituto Oswaldo Cruz.
• Subjects: cold acclimatization; brown adipose tissue; histamine; tissue growth
• Online Access: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02761998000200016

Cold acclimatization (4-5°C) is accompanied by 2-3 fold increase of brown adipose tissue (BAT). This rapid growth of interscapular BAT was studied after histamine depletion. In control rats maintained at room temperature (28 ± 2°C) the BAT histamine content was 23.4 ± 5.9 (mean ± SD) µg/g of tissue and cold acclimatization (5±1°C) produced a significant increase of BAT weight, but reduced the histamine content to 8.4 ± 1.9 µg/g. The total weight of BAT after 20 days of acclimatization was unaffected by depletion of histamine due to compound 48/80. The low level of histamine in BAT of cold acclimatized rats could be due to a fast rate of amine utilization; alternatively an altered synthesis or storage process may occur during acclimatization.