Collagen matrix compared with mitomycin C for treatment of primary open-angle glaucoma with trabeculectomy performed

• Main Authors: Lei Yu, Hong Qin
• Format: Article
• Language: English
• Published: Press of International Journal of Ophthalmology (IJO PRESS) 2017-09-01
• Series: Guoji Yanke Zazhi
• Subjects: open-angle glaucoma; collagen matrix; trabeculectomy; mitomycin C; intraocular pressure; complications
• Online Access: http://ies.ijo.cn/cn_publish/2017/9/201709027.pdf

AIM:To evaluate the effectiveness and safety between trabeculectomy with collagen matrix versus trabeculectomy with mitomycin C(MMC)for patients with primary open-angle glaucoma(POAG).<p>METHODS: In this prospective randomized comparative study from January 2015 to December 2016. Thirty-two eyes presented with POAG were included in this study, 14 eyes treated by trabeculectomy with subconjunctival implant of collagen matrix(study group)and the other 18 eyes treated by trabeculectomy with mitomycin C. Postoperative IOP, the success rate of operation, number of postoperative glaucoma medications and postoperative complications were recorded. Each patient was followed up at least 6mo. <p>RESULTS: The mean postoperative IOP was statistically different between the study group and the control group after 1d(<i>P</i><0.05), while not statistically different at 1 and 1mo follow-up(<i>P</i>>0.05), and the mean postoperative IOP was statistically different between the two groups(<i>P</i><0.05)at 3 and 6mo after surgery. There was no significant difference in the success rate of operation between the two groups at 6mo after operation(<i>P</i>>0.05). The IOP decreased at 1d after openations compared with before, kept stable at 1wk to 6mo. IOP of study group was lowen than control. IOP was controlled by glaucoma medications in the study group by 28% compared to control group by 33% at 6mo after operation, but there was no significant difference. There was no significant difference between the study group and the control group in complications(<i>P</i><0.05).<p>CONCLUSION: Trabeculectomy with collagen matrix implant is comparable to the use of MMC with a similar success rate in open-angle glaucoma and the range in reducing intraocular pressure was significantly higher than that of MMC and it can significantly avoid the occurrence of low IOP postoperatively, transient anterior chamber, conjunctival wound leakage complications has no advantages compared with the use of MMC.