Comparison Of Less Invasive Surfactant Delivery Techniques In Respiratory Distress Syndrome

• Main Authors: Yasemin Çoban, Erdal Taşkın
• Format: Article
• Language: English
• Published: Rabia Yılmaz 2020-12-01
• Series: Journal of Contemporary Medicine
• Subjects: respiratory distress syndrome; surfactant; complications; new method; respiratuar distres sendromu; surfaktan; komplikasyon; veriliş yöntemi; cpap
• Online Access: https://dergipark.org.tr/tr/pub/jcm/issue/54171/712931

Background: This study was conducted to evaluate and compare the effectiveness of newly developed minimal invasive methods for surfactant administration (LISA by using Magill forceps, INSURE) Methods: The research was conducted on 15 patients between 685-2100 gr weight, requiring surfactant administration. Poractant alpha, dose 200 mg/kg, was administered to patients with spontaneous breathing on continuous positive airway pressure support. LISA was used to administer surfactant to 7 of 15 patients, whereas 8 of them had surfactant administered using the INSURE method. Results: The data regarding the delivery method, birth weight, gender, prenatal history, usage of steroids, APGAR scores and other data about the patients until hospital discharge were recorded. Desaturation and bradycardia for 3-4 minutes were observed in 71% (5/7) of LISA and 87.5% (7/8) of INSURE cases. Bradycardia was observed in 4 of 8 patients from the INSURE group and positive ventilation was needed. From the INSURE group, 3 patients died; one of 15 had ROP and this patient was from the INSURE group. No difference was found among the groups regarding required duration of O2 and days of hospital stay (p<0.05). The thin catheter group had significantly fewer median days on mechanical ventilation and lower rate of mortality (p<0.05). Conclusions: When there is no need for mechanical ventilation, intubation for surfactant administration was determined not to be necessary in the present study. LISA was observed to be the best method for surfactant administration among the methods without intubation.