A Case of Rituximab-Induced Necrotizing Fasciitis and a Review of the Literature

A Case of Rituximab-Induced Necrotizing Fasciitis and a Review of the Literature

Necrotizing fasciitis is a fulminant soft tissue infection characterized by rapid progression and high mortality. Rituximab is a generally well-tolerated immunosuppresive medication used for B-cell malignancies and some rheumatological disorders. We report a case of a 69-year-old male with chronic l...

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Main Authors: Abdullateef Abdulkareem, Ryan S. D’Souza, Oluwaseun Shogbesan, Anthony Donato
Format: Article
Language:English
Published: Hindawi Limited 2017-01-01
Series:Case Reports in Hematology
Online Access:http://dx.doi.org/10.1155/2017/6971027
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spelling doaj-0602b16b148d440291998face49626832020-11-25T01:05:08ZengHindawi LimitedCase Reports in Hematology2090-65602090-65792017-01-01201710.1155/2017/69710276971027A Case of Rituximab-Induced Necrotizing Fasciitis and a Review of the LiteratureAbdullateef Abdulkareem0Ryan S. D’Souza1Oluwaseun Shogbesan2Anthony Donato3Department of Medicine, Reading Hospital, West Reading, PA, USADepartment of Medicine, Reading Hospital, West Reading, PA, USADepartment of Medicine, Reading Hospital, West Reading, PA, USADepartment of Medicine, Reading Hospital, West Reading, PA, USANecrotizing fasciitis is a fulminant soft tissue infection characterized by rapid progression and high mortality. Rituximab is a generally well-tolerated immunosuppresive medication used for B-cell malignancies and some rheumatological disorders. We report a case of a 69-year-old male with chronic lymphocytic leukemia who suffered necrotizing fasciitis of his left lower extremity secondary to Clostridium septicum 7 weeks after treatment with rituximab. Despite immediate intravenous antimicrobial therapy and emergent fasciotomy with extensive debridement, his hospital course was complicated by septic shock and he required an above-the-knee amputation. Physicians need to be aware of the possibility of necrotizing fasciitis in patients presenting with skin infections after rituximab therapy.http://dx.doi.org/10.1155/2017/6971027
collection DOAJ
language English
format Article
sources DOAJ
author Abdullateef Abdulkareem
Ryan S. D’Souza
Oluwaseun Shogbesan
Anthony Donato
spellingShingle Abdullateef Abdulkareem
Ryan S. D’Souza
Oluwaseun Shogbesan
Anthony Donato
A Case of Rituximab-Induced Necrotizing Fasciitis and a Review of the Literature
Case Reports in Hematology
author_facet Abdullateef Abdulkareem
Ryan S. D’Souza
Oluwaseun Shogbesan
Anthony Donato
author_sort Abdullateef Abdulkareem
title A Case of Rituximab-Induced Necrotizing Fasciitis and a Review of the Literature
title_short A Case of Rituximab-Induced Necrotizing Fasciitis and a Review of the Literature
title_full A Case of Rituximab-Induced Necrotizing Fasciitis and a Review of the Literature
title_fullStr A Case of Rituximab-Induced Necrotizing Fasciitis and a Review of the Literature
title_full_unstemmed A Case of Rituximab-Induced Necrotizing Fasciitis and a Review of the Literature
title_sort case of rituximab-induced necrotizing fasciitis and a review of the literature
publisher Hindawi Limited
series Case Reports in Hematology
issn 2090-6560
2090-6579
publishDate 2017-01-01
description Necrotizing fasciitis is a fulminant soft tissue infection characterized by rapid progression and high mortality. Rituximab is a generally well-tolerated immunosuppresive medication used for B-cell malignancies and some rheumatological disorders. We report a case of a 69-year-old male with chronic lymphocytic leukemia who suffered necrotizing fasciitis of his left lower extremity secondary to Clostridium septicum 7 weeks after treatment with rituximab. Despite immediate intravenous antimicrobial therapy and emergent fasciotomy with extensive debridement, his hospital course was complicated by septic shock and he required an above-the-knee amputation. Physicians need to be aware of the possibility of necrotizing fasciitis in patients presenting with skin infections after rituximab therapy.
url http://dx.doi.org/10.1155/2017/6971027
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