CO, Pb++ and SO2 effects on L-type calcium channel and action potential in human atrial myocytes. In silico study

CO, Pb++ and SO2 effects on L-type calcium channel and action potential in human atrial myocytes. In silico study

Exposure to air pollutants like carbon monoxide (CO), lead (Pb++) and sulfur dioxide (SO2) promotes the occurrence of cardiovascular diseases. Experimental studies have shown that CO, Pb++ and SO2 block L-type calcium channels, reducing the calcium current (ICaL) and the action potential duration (A...

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Bibliographic Details
Main Authors: Diana C. Pachajoa, Catalina Tobón, Juan P. Ugarte, Javier Saiz
Format: Article
Language:English
Published: Instituto Tecnológico Metropolitano 2017-09-01
Series:TecnoLógicas
Subjects:
Air pollution
atrial action potential
calcium channel
in silico models
Online Access:http://itmojs.itm.edu.co/index.php/tecnologicas/article/view/1138/984

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