Experimental determination and data-driven prediction of homotypic transmembrane domain interfaces

Experimental determination and data-driven prediction of homotypic transmembrane domain interfaces

Interactions between their transmembrane domains (TMDs) frequently support the assembly of single-pass membrane proteins to non-covalent complexes. Yet, the TMD-TMD interactome remains largely uncharted. With a view to predicting homotypic TMD-TMD interfaces from primary structure, we performed a sy...

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Bibliographic Details
Main Authors: Yao Xiao, Bo Zeng, Nicola Berner, Dmitrij Frishman, Dieter Langosch, Mark George Teese
Format: Article
Language:English
Published: Elsevier 2020-01-01
Series:Computational and Structural Biotechnology Journal
Subjects:
Protein-protein interaction
TMD interactions
Machine learning
Transmembrane
GxxxG
Co-evolution
Online Access:http://www.sciencedirect.com/science/article/pii/S2001037020304190

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http://www.sciencedirect.com/science/article/pii/S2001037020304190

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