Activation of Cryptic 3′ Splice-Sites by SRSF2 Contributes to Cassette Exon Skipping

Activation of Cryptic 3′ Splice-Sites by SRSF2 Contributes to Cassette Exon Skipping

Here we show that the serine/arginine rich splicing factor 2 (SRSF2) promotes cryptic 3′ splice-site (3′AG′) usage during cassette exon exclusion in survival of motor neuron (SMN2) minigenes. Deletion of the 3′AG′ (3′AG′1), its as...

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Bibliographic Details
Main Authors: Heegyum Moon, Ha Na Jang, Yongchao Liu, Namjeong Choi, Jagyeong Oh, Jiyeon Ha, Xuexiu Zheng, Haihong Shen
Format: Article
Language:English
Published: MDPI AG 2019-07-01
Series:Cells
Subjects:
SRSF2
cryptic 3′ splice-site
exon exclusion
intron retention
pre-mRNA splicing
Online Access:https://www.mdpi.com/2073-4409/8/7/696

Internet

https://www.mdpi.com/2073-4409/8/7/696

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