| Summary: | Background: Lifestyle habits strongly influence health. It is strongly believed that physical activity may improve cognitive function. We examined the association between two kinds of physical activity and cognitive function in patients with type 2 diabetes. Methods: Using a random allocation sequence, 49 patients with type 2 diabetes (metformin, insulin, and diet-controlled) were randomized to a 12-week intervention of either walking 40 min three times a week (<i>n</i> = 17), performing pedometer-controlled activity (E-health, goal 10,000 steps a day, <i>n</i> = 17), or receiving standard care (<i>n</i> = 16 controls). We prospectively examined cognitive function, metabolic parameters, height, and weight. The groups were compared using linear regression adjusted for age. Results: Compared with the control group (<i>n</i> = 16), nonverbal memory improved significantly after the intervention in the walking group (<i>n</i> = 16) (28.2 (+/−6.1) vs. 35.3 (+/−5.3) <i>p</i> < 0.001) and the E-health (pedometer) group ((<i>n</i> = 17) (29.7 (+/−3.9) vs. 35.6 (+/−3.8) <i>p</i> < 0.001). The verbal memory test showed improvement in the walking and E-health groups. Cognitive attention/performance measured by the FAIR-test was also significantly enhanced in the walking group (252.4/304.3 <i>p</i> < 0.001, 51.87 (CI 27.13–76.62)) and the E-health-group (85.65 (CI: 52.04–119.26, <i>p</i> < 0.001)). Abdominal circumference (−3 cm (CI: −9.69–3.31, <i>p</i> < 0.001)), heart rate (−6.50 (CI: −9.69, −3.31, <i>p</i> < 0.001)) and fat percentage (−2.74 (CI: −4.71, −0.76, <i>p</i> < 0.007)) changed significantly in only the walking group. Conclusions: This is the first intervention study in patients with type 2 diabetes that shows that pedometer-supported training significantly improves brain function. Walking additionally improves body composition and waist circumference. Physical activity is an inexpensive treatment with substantial preventative and restorative properties for cognitive and memory brain function in patients with type 2 diabetes.
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