OCT1-Mediated Metformin Uptake Regulates Pancreatic Stellate Cell Activity

OCT1-Mediated Metformin Uptake Regulates Pancreatic Stellate Cell Activity

Background/Aims: Metformin treatment is reported to be associated with a lower incidence of and mortality from pancreatic cancer (PC) in type 2 diabetes patients. Activated pancreatic stellate cells (PSCs) are key stroma cells responsible for pancreatic fibrogenesis and PC progression. However, litt...

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Bibliographic Details
Main Authors: Chunhua Wu, Shanhu Qiu, Xiangyun Zhu, Hao Lin, Ling Li
Format: Article
Language:English
Published: Cell Physiol Biochem Press GmbH & Co KG 2018-06-01
Series:Cellular Physiology and Biochemistry
Subjects:
Metformin
Pancreatic stellate cells
Proliferation
Phosphorylated AMPK
Organic cation transporter member 1
Online Access:https://www.karger.com/Article/FullText/491003

Internet

https://www.karger.com/Article/FullText/491003

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