The Role of TGF-β Signaling in Lung Cancer Associated with Idiopathic Pulmonary Fibrosis

Idiopathic pulmonary fibrosis (IPF) is a progressive fibrotic lung disease of unknown etiology and dismal prognosis. IPF patients are known to have an increased risk of lung cancer and careful decision-making is required for the treatment of lung cancer associated with IPF. Transforming growth facto...

Full description

Bibliographic Details
Main Authors:	Akira Saito, Masafumi Horie, Patrick Micke, Takahide Nagase
Format:	Article
Language:	English
Published:	MDPI AG 2018-11-01
Series:	International Journal of Molecular Sciences
Subjects:	idiopathic pulmonary fibrosis non-small cell lung cancer transforming growth factor-β extracellular matrix tumor microenvironment usual interstitial pneumonia
Online Access:	https://www.mdpi.com/1422-0067/19/11/3611

id	doaj-05ef8d1583ec42af9020ab5d117cfcb7
record_format	Article
spelling	doaj-05ef8d1583ec42af9020ab5d117cfcb72020-11-24T23:11:56ZengMDPI AGInternational Journal of Molecular Sciences1422-00672018-11-011911361110.3390/ijms19113611ijms19113611The Role of TGF-β Signaling in Lung Cancer Associated with Idiopathic Pulmonary FibrosisAkira Saito0Masafumi Horie1Patrick Micke2Takahide Nagase3Department of Respiratory Medicine, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, JapanDepartment of Respiratory Medicine, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, JapanDepartment of Immunology, Genetics and Pathology, Uppsala University, SE-75185 Uppsala, SwedenDepartment of Respiratory Medicine, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, JapanIdiopathic pulmonary fibrosis (IPF) is a progressive fibrotic lung disease of unknown etiology and dismal prognosis. IPF patients are known to have an increased risk of lung cancer and careful decision-making is required for the treatment of lung cancer associated with IPF. Transforming growth factor (TGF)-β signaling plays a central role in tissue fibrosis and tumorigenesis. TGF-β-mediated pathological changes that occur in IPF lung tissue may promote the process of field cancerization and provide the microenvironment favorable to cancer initiation and progression. This review summarizes the current knowledge related to IPF pathogenesis and explores the molecular mechanisms that underlie the occurrence of lung cancer in the background of IPF, with an emphasis on the multifaceted effects of TGF-β signaling.https://www.mdpi.com/1422-0067/19/11/3611idiopathic pulmonary fibrosisnon-small cell lung cancertransforming growth factor-βextracellular matrixtumor microenvironmentusual interstitial pneumonia
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Akira Saito Masafumi Horie Patrick Micke Takahide Nagase
spellingShingle	Akira Saito Masafumi Horie Patrick Micke Takahide Nagase The Role of TGF-β Signaling in Lung Cancer Associated with Idiopathic Pulmonary Fibrosis International Journal of Molecular Sciences idiopathic pulmonary fibrosis non-small cell lung cancer transforming growth factor-β extracellular matrix tumor microenvironment usual interstitial pneumonia
author_facet	Akira Saito Masafumi Horie Patrick Micke Takahide Nagase
author_sort	Akira Saito
title	The Role of TGF-β Signaling in Lung Cancer Associated with Idiopathic Pulmonary Fibrosis
title_short	The Role of TGF-β Signaling in Lung Cancer Associated with Idiopathic Pulmonary Fibrosis
title_full	The Role of TGF-β Signaling in Lung Cancer Associated with Idiopathic Pulmonary Fibrosis
title_fullStr	The Role of TGF-β Signaling in Lung Cancer Associated with Idiopathic Pulmonary Fibrosis
title_full_unstemmed	The Role of TGF-β Signaling in Lung Cancer Associated with Idiopathic Pulmonary Fibrosis
title_sort	role of tgf-β signaling in lung cancer associated with idiopathic pulmonary fibrosis
publisher	MDPI AG
series	International Journal of Molecular Sciences
issn	1422-0067
publishDate	2018-11-01
description	Idiopathic pulmonary fibrosis (IPF) is a progressive fibrotic lung disease of unknown etiology and dismal prognosis. IPF patients are known to have an increased risk of lung cancer and careful decision-making is required for the treatment of lung cancer associated with IPF. Transforming growth factor (TGF)-β signaling plays a central role in tissue fibrosis and tumorigenesis. TGF-β-mediated pathological changes that occur in IPF lung tissue may promote the process of field cancerization and provide the microenvironment favorable to cancer initiation and progression. This review summarizes the current knowledge related to IPF pathogenesis and explores the molecular mechanisms that underlie the occurrence of lung cancer in the background of IPF, with an emphasis on the multifaceted effects of TGF-β signaling.
topic	idiopathic pulmonary fibrosis non-small cell lung cancer transforming growth factor-β extracellular matrix tumor microenvironment usual interstitial pneumonia
url	https://www.mdpi.com/1422-0067/19/11/3611
work_keys_str_mv	AT akirasaito theroleoftgfbsignalinginlungcancerassociatedwithidiopathicpulmonaryfibrosis AT masafumihorie theroleoftgfbsignalinginlungcancerassociatedwithidiopathicpulmonaryfibrosis AT patrickmicke theroleoftgfbsignalinginlungcancerassociatedwithidiopathicpulmonaryfibrosis AT takahidenagase theroleoftgfbsignalinginlungcancerassociatedwithidiopathicpulmonaryfibrosis AT akirasaito roleoftgfbsignalinginlungcancerassociatedwithidiopathicpulmonaryfibrosis AT masafumihorie roleoftgfbsignalinginlungcancerassociatedwithidiopathicpulmonaryfibrosis AT patrickmicke roleoftgfbsignalinginlungcancerassociatedwithidiopathicpulmonaryfibrosis AT takahidenagase roleoftgfbsignalinginlungcancerassociatedwithidiopathicpulmonaryfibrosis
_version_	1725603327657377792

The Role of TGF-β Signaling in Lung Cancer Associated with Idiopathic Pulmonary Fibrosis

Similar Items