The Role of TGF-β Signaling in Lung Cancer Associated with Idiopathic Pulmonary Fibrosis

The Role of TGF-β Signaling in Lung Cancer Associated with Idiopathic Pulmonary Fibrosis

Idiopathic pulmonary fibrosis (IPF) is a progressive fibrotic lung disease of unknown etiology and dismal prognosis. IPF patients are known to have an increased risk of lung cancer and careful decision-making is required for the treatment of lung cancer associated with IPF. Transforming growth facto...

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Bibliographic Details
Main Authors: Akira Saito, Masafumi Horie, Patrick Micke, Takahide Nagase
Format: Article
Language:English
Published: MDPI AG 2018-11-01
Series:International Journal of Molecular Sciences
Subjects:
idiopathic pulmonary fibrosis
non-small cell lung cancer
transforming growth factor-β
extracellular matrix
tumor microenvironment
usual interstitial pneumonia
Online Access:https://www.mdpi.com/1422-0067/19/11/3611
Description
Summary:Idiopathic pulmonary fibrosis (IPF) is a progressive fibrotic lung disease of unknown etiology and dismal prognosis. IPF patients are known to have an increased risk of lung cancer and careful decision-making is required for the treatment of lung cancer associated with IPF. Transforming growth factor (TGF)-β signaling plays a central role in tissue fibrosis and tumorigenesis. TGF-β-mediated pathological changes that occur in IPF lung tissue may promote the process of field cancerization and provide the microenvironment favorable to cancer initiation and progression. This review summarizes the current knowledge related to IPF pathogenesis and explores the molecular mechanisms that underlie the occurrence of lung cancer in the background of IPF, with an emphasis on the multifaceted effects of TGF-β signaling.
ISSN:1422-0067

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