Methods for Arylethylation of Amines and Heteroarenes

Abstract Compared with standard N-methylation, benzylation, and alkylation of amines and N-heterocycles, N-arylethylation is significantly more challenging. In this Review the available methods for N-arylethylation are summarized, with a special focus on efficiency, selectivity, availability of the...

Full description

Bibliographic Details
Main Author:	Franz Bracher
Format:	Article
Language:	English
Published:	Georg Thieme Verlag KG 2018-04-01
Series:	SynOpen
Subjects:	arylethylation phenethylation alkylation reductive amination hydroamination reduction
Online Access:	http://www.thieme-connect.de/DOI/DOI?10.1055/s-0037-1609449

id	doaj-05ebd9fc937c415fae2ee9d22e506915
record_format	Article
spelling	doaj-05ebd9fc937c415fae2ee9d22e5069152020-11-25T02:32:40ZengGeorg Thieme Verlag KGSynOpen2509-93962018-04-0102020096010410.1055/s-0037-1609449Methods for Arylethylation of Amines and HeteroarenesFranz Bracher0Department of Pharmacy – Center for Drug Research, Ludwig-Maximilians UniversityAbstract Compared with standard N-methylation, benzylation, and alkylation of amines and N-heterocycles, N-arylethylation is significantly more challenging. In this Review the available methods for N-arylethylation are summarized, with a special focus on efficiency, selectivity, availability of the required building blocks, and ecological aspects.http://www.thieme-connect.de/DOI/DOI?10.1055/s-0037-1609449arylethylationphenethylationalkylationreductive aminationhydroaminationreduction
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Franz Bracher
spellingShingle	Franz Bracher Methods for Arylethylation of Amines and Heteroarenes SynOpen arylethylation phenethylation alkylation reductive amination hydroamination reduction
author_facet	Franz Bracher
author_sort	Franz Bracher
title	Methods for Arylethylation of Amines and Heteroarenes
title_short	Methods for Arylethylation of Amines and Heteroarenes
title_full	Methods for Arylethylation of Amines and Heteroarenes
title_fullStr	Methods for Arylethylation of Amines and Heteroarenes
title_full_unstemmed	Methods for Arylethylation of Amines and Heteroarenes
title_sort	methods for arylethylation of amines and heteroarenes
publisher	Georg Thieme Verlag KG
series	SynOpen
issn	2509-9396
publishDate	2018-04-01
description	Abstract Compared with standard N-methylation, benzylation, and alkylation of amines and N-heterocycles, N-arylethylation is significantly more challenging. In this Review the available methods for N-arylethylation are summarized, with a special focus on efficiency, selectivity, availability of the required building blocks, and ecological aspects.
topic	arylethylation phenethylation alkylation reductive amination hydroamination reduction
url	http://www.thieme-connect.de/DOI/DOI?10.1055/s-0037-1609449
work_keys_str_mv	AT franzbracher methodsforarylethylationofaminesandheteroarenes
_version_	1724818551407116288

Methods for Arylethylation of Amines and Heteroarenes

Similar Items