SUMO-interacting motifs of human TRIM5α are important for antiviral activity.

SUMO-interacting motifs of human TRIM5α are important for antiviral activity.

Human TRIM5α potently restricts particular strains of murine leukemia viruses (the so-called N-tropic strains) but not others (the B- or NB-tropic strains) during early stages of infection. We show that overexpression of SUMO-1 in human 293T cells, but not in mouse MDTF cells, profoundly blocks N-ML...

Full description

Bibliographic Details
Main Authors: Gloria Arriagada, Lucia N Muntean, Stephen P Goff
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-04-01
Series:PLoS Pathogens
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/21490953/pdf/?tool=EBI

Similar Items

Similar Items