Green and Facile Synthesis of Spirocyclopentanes Through NaOH-Promoted Chemo- and Diastereo-Selective (3 + 2) Cycloaddition Reactions of Activated Cyclopropanes and Enamides

Green and Facile Synthesis of Spirocyclopentanes Through NaOH-Promoted Chemo- and Diastereo-Selective (3 + 2) Cycloaddition Reactions of Activated Cyclopropanes and Enamides

A chemo- and diastereo-selective (3 + 2) cycloaddition reacition between Donor-Acceptor (D-A) cyclopropanes and α,β-unsaturated enamides is developed for efficient access to spiro(cyclopentane-1,3'-indoline) derivatives. Simple, inexpensive and readily available NaOH is used as the sole catalys...

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Bibliographic Details
Main Authors: Xun Zhu, Dingwu Pan, Chengli Mou, Bo Zhou, Lutai Pan, Zhichao Jin
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-06-01
Series:Frontiers in Chemistry
Subjects:
green
NaOH
donor-acceptor cyclopropane
(3 + 2) cycloaddition
spirocyclopentane
indole derivative
Online Access:https://www.frontiersin.org/article/10.3389/fchem.2020.00542/full

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