Cyclohexanone and Phenolic Acid Derivatives from Endophytic Fungus Diaporthe foeniculina
Chemical investigation of an endophytic fungus Diaporthe foeniculina SCBG-15, led to the isolation of eight new cyclohexanone derivatives, foeniculins A–H (1–8) and three new phenolic acid derivatives, foeniculins I–K (9–11). Their structures were extensively established on the basis of 1H and 13C N...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2021-09-01
|
| Series: | Frontiers in Chemistry |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fchem.2021.738307/full |
| id |
doaj-05d92aa64d4f42d9900163f90287fd88 |
|---|---|
| record_format |
Article |
| spelling |
doaj-05d92aa64d4f42d9900163f90287fd882021-09-03T23:20:35ZengFrontiers Media S.A.Frontiers in Chemistry2296-26462021-09-01910.3389/fchem.2021.738307738307Cyclohexanone and Phenolic Acid Derivatives from Endophytic Fungus Diaporthe foeniculinaXiuxiang Lu0Xiuxiang Lu1Yanjiang Zhang2Yanjiang Zhang3Wenge Zhang4Wenge Zhang5Huan Wang6Huan Wang7Jun Zhang8Sasa Wang9Haibo Tan10Haibo Tan11Key Laboratory of Plant Resources Conservation and Sustainable Utilization, Guangdong Provincial Key Laboratory of Applied Botany, South China Botanical Garden, Chinese Academy of Sciences, Guangzhou, ChinaUniversity of Chinese Academy of Sciences, Beijing, ChinaKey Laboratory of Plant Resources Conservation and Sustainable Utilization, Guangdong Provincial Key Laboratory of Applied Botany, South China Botanical Garden, Chinese Academy of Sciences, Guangzhou, ChinaUniversity of Chinese Academy of Sciences, Beijing, ChinaKey Laboratory of Plant Resources Conservation and Sustainable Utilization, Guangdong Provincial Key Laboratory of Applied Botany, South China Botanical Garden, Chinese Academy of Sciences, Guangzhou, ChinaUniversity of Chinese Academy of Sciences, Beijing, ChinaKey Laboratory of Plant Resources Conservation and Sustainable Utilization, Guangdong Provincial Key Laboratory of Applied Botany, South China Botanical Garden, Chinese Academy of Sciences, Guangzhou, ChinaNational Engineering Research Center of Navel Orange, Gannan Normal University, Ganzhou, ChinaNational Engineering Research Center of Navel Orange, Gannan Normal University, Ganzhou, ChinaKey Laboratory of Chemistry and Engineering of Forest Products, Guangxi University for Nationalities, Nanning, ChinaKey Laboratory of Plant Resources Conservation and Sustainable Utilization, Guangdong Provincial Key Laboratory of Applied Botany, South China Botanical Garden, Chinese Academy of Sciences, Guangzhou, ChinaNational Engineering Research Center of Navel Orange, Gannan Normal University, Ganzhou, ChinaChemical investigation of an endophytic fungus Diaporthe foeniculina SCBG-15, led to the isolation of eight new cyclohexanone derivatives, foeniculins A–H (1–8) and three new phenolic acid derivatives, foeniculins I–K (9–11). Their structures were extensively established on the basis of 1H and 13C NMR spectra together with COSY, HSQC, HMBC, and NOESY experiments. The absolute configurations were confirmed by quantum chemical ECD calculations and single-crystal X-ray diffractions. Moreover, the in vitro cytotoxic and antibacterial activities of isolated compounds 1–11 were also evaluated.https://www.frontiersin.org/articles/10.3389/fchem.2021.738307/fullDiaporthe foeniculinaLeptospermum brachyandrumfoeniculins A-Kcytotoxic activityantibacterial activity |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Xiuxiang Lu Xiuxiang Lu Yanjiang Zhang Yanjiang Zhang Wenge Zhang Wenge Zhang Huan Wang Huan Wang Jun Zhang Sasa Wang Haibo Tan Haibo Tan |
| spellingShingle |
Xiuxiang Lu Xiuxiang Lu Yanjiang Zhang Yanjiang Zhang Wenge Zhang Wenge Zhang Huan Wang Huan Wang Jun Zhang Sasa Wang Haibo Tan Haibo Tan Cyclohexanone and Phenolic Acid Derivatives from Endophytic Fungus Diaporthe foeniculina Frontiers in Chemistry Diaporthe foeniculina Leptospermum brachyandrum foeniculins A-K cytotoxic activity antibacterial activity |
| author_facet |
Xiuxiang Lu Xiuxiang Lu Yanjiang Zhang Yanjiang Zhang Wenge Zhang Wenge Zhang Huan Wang Huan Wang Jun Zhang Sasa Wang Haibo Tan Haibo Tan |
| author_sort |
Xiuxiang Lu |
| title |
Cyclohexanone and Phenolic Acid Derivatives from Endophytic Fungus Diaporthe foeniculina |
| title_short |
Cyclohexanone and Phenolic Acid Derivatives from Endophytic Fungus Diaporthe foeniculina |
| title_full |
Cyclohexanone and Phenolic Acid Derivatives from Endophytic Fungus Diaporthe foeniculina |
| title_fullStr |
Cyclohexanone and Phenolic Acid Derivatives from Endophytic Fungus Diaporthe foeniculina |
| title_full_unstemmed |
Cyclohexanone and Phenolic Acid Derivatives from Endophytic Fungus Diaporthe foeniculina |
| title_sort |
cyclohexanone and phenolic acid derivatives from endophytic fungus diaporthe foeniculina |
| publisher |
Frontiers Media S.A. |
| series |
Frontiers in Chemistry |
| issn |
2296-2646 |
| publishDate |
2021-09-01 |
| description |
Chemical investigation of an endophytic fungus Diaporthe foeniculina SCBG-15, led to the isolation of eight new cyclohexanone derivatives, foeniculins A–H (1–8) and three new phenolic acid derivatives, foeniculins I–K (9–11). Their structures were extensively established on the basis of 1H and 13C NMR spectra together with COSY, HSQC, HMBC, and NOESY experiments. The absolute configurations were confirmed by quantum chemical ECD calculations and single-crystal X-ray diffractions. Moreover, the in vitro cytotoxic and antibacterial activities of isolated compounds 1–11 were also evaluated. |
| topic |
Diaporthe foeniculina Leptospermum brachyandrum foeniculins A-K cytotoxic activity antibacterial activity |
| url |
https://www.frontiersin.org/articles/10.3389/fchem.2021.738307/full |
| work_keys_str_mv |
AT xiuxianglu cyclohexanoneandphenolicacidderivativesfromendophyticfungusdiaporthefoeniculina AT xiuxianglu cyclohexanoneandphenolicacidderivativesfromendophyticfungusdiaporthefoeniculina AT yanjiangzhang cyclohexanoneandphenolicacidderivativesfromendophyticfungusdiaporthefoeniculina AT yanjiangzhang cyclohexanoneandphenolicacidderivativesfromendophyticfungusdiaporthefoeniculina AT wengezhang cyclohexanoneandphenolicacidderivativesfromendophyticfungusdiaporthefoeniculina AT wengezhang cyclohexanoneandphenolicacidderivativesfromendophyticfungusdiaporthefoeniculina AT huanwang cyclohexanoneandphenolicacidderivativesfromendophyticfungusdiaporthefoeniculina AT huanwang cyclohexanoneandphenolicacidderivativesfromendophyticfungusdiaporthefoeniculina AT junzhang cyclohexanoneandphenolicacidderivativesfromendophyticfungusdiaporthefoeniculina AT sasawang cyclohexanoneandphenolicacidderivativesfromendophyticfungusdiaporthefoeniculina AT haibotan cyclohexanoneandphenolicacidderivativesfromendophyticfungusdiaporthefoeniculina AT haibotan cyclohexanoneandphenolicacidderivativesfromendophyticfungusdiaporthefoeniculina |
| _version_ |
1717815642634059776 |