Cyclohexanone and Phenolic Acid Derivatives from Endophytic Fungus Diaporthe foeniculina

Cyclohexanone and Phenolic Acid Derivatives from Endophytic Fungus Diaporthe foeniculina

Chemical investigation of an endophytic fungus Diaporthe foeniculina SCBG-15, led to the isolation of eight new cyclohexanone derivatives, foeniculins A–H (1–8) and three new phenolic acid derivatives, foeniculins I–K (9–11). Their structures were extensively established on the basis of 1H and 13C N...

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Bibliographic Details
Main Authors: Xiuxiang Lu, Yanjiang Zhang, Wenge Zhang, Huan Wang, Jun Zhang, Sasa Wang, Haibo Tan
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-09-01
Series:Frontiers in Chemistry
Subjects:
Diaporthe foeniculina
Leptospermum brachyandrum
foeniculins A-K
cytotoxic activity
antibacterial activity
Online Access:https://www.frontiersin.org/articles/10.3389/fchem.2021.738307/full
Description
Summary:Chemical investigation of an endophytic fungus Diaporthe foeniculina SCBG-15, led to the isolation of eight new cyclohexanone derivatives, foeniculins A–H (1–8) and three new phenolic acid derivatives, foeniculins I–K (9–11). Their structures were extensively established on the basis of 1H and 13C NMR spectra together with COSY, HSQC, HMBC, and NOESY experiments. The absolute configurations were confirmed by quantum chemical ECD calculations and single-crystal X-ray diffractions. Moreover, the in vitro cytotoxic and antibacterial activities of isolated compounds 1–11 were also evaluated.
ISSN:2296-2646

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