Bridging non-overlapping reads illuminates high-order epistasis between distal protein sites in a GPCR

Epistasis effects among amino acids at distal sites within binding pockets can have important impacts on protein fitness landscapes. Here the authors present BRIDGE, which matches non-overlapping sequence reads with their cognate DNA templates.

Bibliographic Details
Main Authors:	Justin I. Yoo, Patrick S. Daugherty, Michelle A. O’Malley
Format:	Article
Language:	English
Published:	Nature Publishing Group 2020-02-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-020-14495-7

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spelling	doaj-05d4a1f9278e456eb4e1635dc620ccf72021-05-11T08:05:07ZengNature Publishing GroupNature Communications2041-17232020-02-0111111210.1038/s41467-020-14495-7Bridging non-overlapping reads illuminates high-order epistasis between distal protein sites in a GPCRJustin I. Yoo0Patrick S. Daugherty1Michelle A. O’Malley2Department of Chemical Engineering, University of California Santa BarbaraDepartment of Chemical Engineering, University of California Santa BarbaraDepartment of Chemical Engineering, University of California Santa BarbaraEpistasis effects among amino acids at distal sites within binding pockets can have important impacts on protein fitness landscapes. Here the authors present BRIDGE, which matches non-overlapping sequence reads with their cognate DNA templates.https://doi.org/10.1038/s41467-020-14495-7
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Justin I. Yoo Patrick S. Daugherty Michelle A. O’Malley
spellingShingle	Justin I. Yoo Patrick S. Daugherty Michelle A. O’Malley Bridging non-overlapping reads illuminates high-order epistasis between distal protein sites in a GPCR Nature Communications
author_facet	Justin I. Yoo Patrick S. Daugherty Michelle A. O’Malley
author_sort	Justin I. Yoo
title	Bridging non-overlapping reads illuminates high-order epistasis between distal protein sites in a GPCR
title_short	Bridging non-overlapping reads illuminates high-order epistasis between distal protein sites in a GPCR
title_full	Bridging non-overlapping reads illuminates high-order epistasis between distal protein sites in a GPCR
title_fullStr	Bridging non-overlapping reads illuminates high-order epistasis between distal protein sites in a GPCR
title_full_unstemmed	Bridging non-overlapping reads illuminates high-order epistasis between distal protein sites in a GPCR
title_sort	bridging non-overlapping reads illuminates high-order epistasis between distal protein sites in a gpcr
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2020-02-01
description	Epistasis effects among amino acids at distal sites within binding pockets can have important impacts on protein fitness landscapes. Here the authors present BRIDGE, which matches non-overlapping sequence reads with their cognate DNA templates.
url	https://doi.org/10.1038/s41467-020-14495-7
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Bridging non-overlapping reads illuminates high-order epistasis between distal protein sites in a GPCR

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