H3K9me3-mediated epigenetic regulation of senescence in mice predicts outcome of lymphoma patients

H3K9me3-mediated epigenetic regulation of senescence in mice predicts outcome of lymphoma patients

Therapy-induced senescence reflects a biological effector principle that is underrecognized in lesion-focused cancer precision medicine. Here the authors utilize mouse lymphoma genetics to functionally dissect senescence and cross-species apply a novel senescence-based prognosticator to lymphoma pat...

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Main Authors: Kolja Schleich, Julia Kase, Jan R. Dörr, Saskia Trescher, Animesh Bhattacharya, Yong Yu, Elizabeth M. Wailes, Dorothy N. Y. Fan, Philipp Lohneis, Maja Milanovic, Andrea Lau, Dido Lenze, Michael Hummel, Bjoern Chapuy, Ulf Leser, Maurice Reimann, Soyoung Lee, Clemens A. Schmitt
Format: Article
Language:English
Published: Nature Publishing Group 2020-07-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-020-17467-z
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spelling doaj-05c76f30d3fb41ad9a1c454ca03278482021-07-25T11:39:38ZengNature Publishing GroupNature Communications2041-17232020-07-0111111410.1038/s41467-020-17467-zH3K9me3-mediated epigenetic regulation of senescence in mice predicts outcome of lymphoma patientsKolja Schleich0Julia Kase1Jan R. Dörr2Saskia Trescher3Animesh Bhattacharya4Yong Yu5Elizabeth M. Wailes6Dorothy N. Y. Fan7Philipp Lohneis8Maja Milanovic9Andrea Lau10Dido Lenze11Michael Hummel12Bjoern Chapuy13Ulf Leser14Maurice Reimann15Soyoung Lee16Clemens A. Schmitt17Charité – University Medical Center, Department of Hematology, Oncology and Tumor Immunology, Virchow Campus, and Molekulares KrebsforschungszentrumCharité – University Medical Center, Department of Hematology, Oncology and Tumor Immunology, Virchow Campus, and Molekulares KrebsforschungszentrumCharité – University Medical Center, Department of Hematology, Oncology and Tumor Immunology, Virchow Campus, and Molekulares KrebsforschungszentrumInstitute for Computer Science, Humboldt-Universität zu BerlinCharité – University Medical Center, Department of Hematology, Oncology and Tumor Immunology, Virchow Campus, and Molekulares KrebsforschungszentrumMax-Delbrück-Center for Molecular Medicine in the Helmholtz AssociationCharité – University Medical Center, Department of Hematology, Oncology and Tumor Immunology, Virchow Campus, and Molekulares KrebsforschungszentrumCharité – University Medical Center, Department of Hematology, Oncology and Tumor Immunology, Virchow Campus, and Molekulares KrebsforschungszentrumUniversity Hospital CologneCharité – University Medical Center, Department of Hematology, Oncology and Tumor Immunology, Virchow Campus, and Molekulares KrebsforschungszentrumCharité – University Medical Center, Department of Hematology, Oncology and Tumor Immunology, Virchow Campus, and Molekulares KrebsforschungszentrumCharité – University Medical CenterDeutsches Konsortium für Translationale Krebsforschung (German Cancer Consortium), Partner Site BerlinUniversity Medical Center Göttingen, Department of Hematology and Medical OncologyInstitute for Computer Science, Humboldt-Universität zu BerlinCharité – University Medical Center, Department of Hematology, Oncology and Tumor Immunology, Virchow Campus, and Molekulares KrebsforschungszentrumCharité – University Medical Center, Department of Hematology, Oncology and Tumor Immunology, Virchow Campus, and Molekulares KrebsforschungszentrumCharité – University Medical Center, Department of Hematology, Oncology and Tumor Immunology, Virchow Campus, and Molekulares KrebsforschungszentrumTherapy-induced senescence reflects a biological effector principle that is underrecognized in lesion-focused cancer precision medicine. Here the authors utilize mouse lymphoma genetics to functionally dissect senescence and cross-species apply a novel senescence-based prognosticator to lymphoma patients.https://doi.org/10.1038/s41467-020-17467-z
collection DOAJ
language English
format Article
sources DOAJ
author Kolja Schleich
Julia Kase
Jan R. Dörr
Saskia Trescher
Animesh Bhattacharya
Yong Yu
Elizabeth M. Wailes
Dorothy N. Y. Fan
Philipp Lohneis
Maja Milanovic
Andrea Lau
Dido Lenze
Michael Hummel
Bjoern Chapuy
Ulf Leser
Maurice Reimann
Soyoung Lee
Clemens A. Schmitt
spellingShingle Kolja Schleich
Julia Kase
Jan R. Dörr
Saskia Trescher
Animesh Bhattacharya
Yong Yu
Elizabeth M. Wailes
Dorothy N. Y. Fan
Philipp Lohneis
Maja Milanovic
Andrea Lau
Dido Lenze
Michael Hummel
Bjoern Chapuy
Ulf Leser
Maurice Reimann
Soyoung Lee
Clemens A. Schmitt
H3K9me3-mediated epigenetic regulation of senescence in mice predicts outcome of lymphoma patients
Nature Communications
author_facet Kolja Schleich
Julia Kase
Jan R. Dörr
Saskia Trescher
Animesh Bhattacharya
Yong Yu
Elizabeth M. Wailes
Dorothy N. Y. Fan
Philipp Lohneis
Maja Milanovic
Andrea Lau
Dido Lenze
Michael Hummel
Bjoern Chapuy
Ulf Leser
Maurice Reimann
Soyoung Lee
Clemens A. Schmitt
author_sort Kolja Schleich
title H3K9me3-mediated epigenetic regulation of senescence in mice predicts outcome of lymphoma patients
title_short H3K9me3-mediated epigenetic regulation of senescence in mice predicts outcome of lymphoma patients
title_full H3K9me3-mediated epigenetic regulation of senescence in mice predicts outcome of lymphoma patients
title_fullStr H3K9me3-mediated epigenetic regulation of senescence in mice predicts outcome of lymphoma patients
title_full_unstemmed H3K9me3-mediated epigenetic regulation of senescence in mice predicts outcome of lymphoma patients
title_sort h3k9me3-mediated epigenetic regulation of senescence in mice predicts outcome of lymphoma patients
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2020-07-01
description Therapy-induced senescence reflects a biological effector principle that is underrecognized in lesion-focused cancer precision medicine. Here the authors utilize mouse lymphoma genetics to functionally dissect senescence and cross-species apply a novel senescence-based prognosticator to lymphoma patients.
url https://doi.org/10.1038/s41467-020-17467-z
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