H3K9me3-mediated epigenetic regulation of senescence in mice predicts outcome of lymphoma patients
Therapy-induced senescence reflects a biological effector principle that is underrecognized in lesion-focused cancer precision medicine. Here the authors utilize mouse lymphoma genetics to functionally dissect senescence and cross-species apply a novel senescence-based prognosticator to lymphoma pat...
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Bibliographic Details
| Main Authors: |
Kolja Schleich,
Julia Kase,
Jan R. Dörr,
Saskia Trescher,
Animesh Bhattacharya,
Yong Yu,
Elizabeth M. Wailes,
Dorothy N. Y. Fan,
Philipp Lohneis,
Maja Milanovic,
Andrea Lau,
Dido Lenze,
Michael Hummel,
Bjoern Chapuy,
Ulf Leser,
Maurice Reimann,
Soyoung Lee,
Clemens A. Schmitt |
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| Format: | Article
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| Language: | English |
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| Published: |
Nature Publishing Group
2020-07-01
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| Series: | Nature Communications
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| Online Access: | https://doi.org/10.1038/s41467-020-17467-z
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