Interferon-γ regulates the proliferation and differentiation of mesenchymal stem cells via activation of indoleamine 2,3 dioxygenase (IDO).

Interferon-γ regulates the proliferation and differentiation of mesenchymal stem cells via activation of indoleamine 2,3 dioxygenase (IDO).

The kynurenine pathway (KP) of tryptophan metabolism is linked to antimicrobial activity and modulation of immune responses but its role in stem cell biology is unknown. We show that human and mouse mesenchymal and neural stem cells (MSCs and NSCs) express the complete KP, including indoleamine 2,3...

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Bibliographic Details
Main Authors: Juliana Croitoru-Lamoury, Francois M J Lamoury, Michael Caristo, Kazuo Suzuki, David Walker, Osamu Takikawa, Rosanne Taylor, Bruce J Brew
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3040184?pdf=render

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http://europepmc.org/articles/PMC3040184?pdf=render

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