Mobilization of endothelial progenitor cells after endovascular interventions in patients with type 2 diabetes mellitus

• Main Authors: Marina Sergeevna Michurova, Victor Yur'evich Kalashnikov, Olga Michailovna Smirnova, Olga Nikolaevna Ivanova, Sergey Anatol'evich Terekhin
• Format: Article
• Language: English
• Published: Endocrinology Research Centre 2014-12-01
• Series: Сахарный диабет
• Subjects: diabetes mellitus; endothelial progenitor cells; mobilisation; percutaneous coronary intervention; lower extremity revascularization
• Online Access: https://dia-endojournals.ru/dia/article/viewFile/6819/4778

Aim. To investigate the mobilisation of endothelial progenitor cells (EPC) in patients with type 2 diabetes mellitus (T2DM) after endovascular interventions for coronary and peripheral arteries. Materials and Methods. The levels of EPC in peripheral blood were determined by flow cytometry in 42 patients prior to endovascular intervention and 2?4 days after surgery. EPC were defined as CD34+ VEGFR2+ CD45- and CD34+ CD133+CD45- cells. Twenty-three patients with T2DM were included in group 1, and 19 patients without metabolic disorders were included in group 2. Results. The levels of EPC in the peripheral blood of patients with T2DM before and after endovascular interventions were not significantly different. In the subgroup of patients without TDM2, the levels of CD34+VEGFR2 +CD45- cells increased after surgery to 55,5% (p