Intrastriatal injection of preformed alpha-synuclein fibrils alters central and peripheral immune cell profiles in non-transgenic mice

Intrastriatal injection of preformed alpha-synuclein fibrils alters central and peripheral immune cell profiles in non-transgenic mice

Abstract Parkinson’s disease (PD) is characterized by the accumulation of alpha-synuclein (α-syn) inclusions, the major component of Lewy bodies. Extracellular α-syn aggregates act as a damage-associated molecular pattern (DAMP) and the presence of autoantibodies against α-syn species in the cerebro...

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Bibliographic Details
Main Authors: Rachael H. Earls, Kelly B. Menees, Jaegwon Chung, James Barber, Claire-Anne Gutekunst, Manuel G. Hazim, Jae-Kyung Lee
Format: Article
Language:English
Published: BMC 2019-12-01
Series:Journal of Neuroinflammation
Subjects:
Neuroinflammation
Synucleinopathies
Immune system
Parkinson’s disease
Animal models
Neurodegeneration
Online Access:https://doi.org/10.1186/s12974-019-1636-8

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