VASCULAR REMODELING IN HYPERTENSION: ANGIOGENESIS FEATURES

• Main Authors: L. A. Haisheva, S. V. Shlyk, A. S. Pleskachev, E. S. Makarenko
• Format: Article
• Language: Russian
• Published: ABV-press 2014-07-01
• Series: Klinicist
• Subjects: hypertension; vascular wall; vascular endothelial growth factor; endostatin
• Online Access: http://klinitsist.abvpress.ru/index.php/Klin/article/view/65

<p><strong>Aim</strong> — cross-sectional study of changes in various segments of the vascular bed in arterial hypertension (AH), defining the role of inducers and inhibitors of angiogenesis in these processes.</p><p><br /><strong>Materials and methods</strong>. The study included 99 patients with arterial hypertension of I–II degree, average age of 63.2 ± 2.6 years, disease<br />duration 9.2 ± 7.2 years.</p><p><br /><strong>Results.</strong> It was found that patients with arterial hypertension have disorders in all segments of vascular bed: endothelial dysfunction (high<br />vWF), microcirculatory disorders, and increased pulse wave velocity (PWV) of elastic-type vessels. The level of angioginesis factors does<br />not depend on such parameters as gender, age, body mass index. Smoking and duration of hypertension influence on vascular endothelial<br />growth factor raise and endostatin levels are higher in patients with family history of cardiovascular diseases. Duration of disease is directly<br />correlated with microcirculatory disorders and the PWV, correlation between microcirculatory disorders and pulse wave velocity indicate<br />their common processes.</p>