Chronotopic and blood pressure response to oral glucose load in chagas' disease

• Main Authors: Maria Elena Guariento, Elza Olga, Ana Muscelli, José Antonio Rocha Gontijo
• Format: Article
• Language: English
• Published: Associação Paulista de Medicina
• Series: São Paulo Medical Journal
• Subjects: Cardiovascular response; insulinemic response; Autonomic Nervous System; South America Trypanosomiasis
• Online Access: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-31801994000300006&lng=en&tlng=en
• ISSN: 1806-9460

Cardiac chronotropic and pressor responses after an oral load of glucose were assessed in sixteen Chagasic subjects and 28 controls by means of blood pressure and pulse rate measurements. Cardiovascular response was correlated with serum insulin and glucose levels. The experiment identified a subgroup of Chagasic subjects (n=8) with a hypoinsulinemic behavior presenting less chronotropic and pressor responses than controls. This may indicate a lower insulin activity and/or an early Autonomic Nervous System dysfunction in this subgroup.