Elastin-Dependent Aortic Heart Valve Leaflet Curvature Changes During Cyclic Flexure

Elastin-Dependent Aortic Heart Valve Leaflet Curvature Changes During Cyclic Flexure

The progression of calcific aortic valve disease (CAVD) is characterized by extracellular matrix (ECM) remodeling, leading to structural abnormalities and improper valve function. The focus of the present study was to relate aortic valve leaflet axial curvature changes as a function of elastin degra...

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Bibliographic Details
Main Authors: Melake D. Tesfamariam, Asad M. Mirza, Daniel Chaparro, Ahmed Z. Ali, Rachel Montalvan, Ilyas Saytashev, Brittany A. Gonzalez, Amanda Barreto, Jessica Ramella-Roman, Joshua D. Hutcheson, Sharan Ramaswamy
Format: Article
Language:English
Published: MDPI AG 2019-05-01
Series:Bioengineering
Subjects:
aortic valve
calcification
elastin degradation
leaflet
curvature
biomarker
early detection
Online Access:https://www.mdpi.com/2306-5354/6/2/39

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