A Novel Transcriptome Integrated Network Approach Identifies the Key Driver lncRNA Involved in Cell Cycle With Chromium (VI)-Treated BEAS-2B Cells

A Novel Transcriptome Integrated Network Approach Identifies the Key Driver lncRNA Involved in Cell Cycle With Chromium (VI)-Treated BEAS-2B Cells

Hexavalent chromium [Cr(VI)] is a well-known occupational carcinogen, but the mechanisms contributing to DNA damage and cell cycle alternation have not been fully characterized. To study the dose-response effects of Cr(VI) on transcription, we exposed BEAS-2B cells to Cr(VI) at concentrations of 0.2...

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Bibliographic Details
Main Authors: Pai Zheng, Yulin Kang, Shuo Han, Huimin Feng, Feizai Ha, Changmao Long, Di Zhou, Guiping Hu, Zhangjian Chen, Zengmiao Wang, Tiancheng Wang, Guang Jia
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-01-01
Series:Frontiers in Genetics
Subjects:
hexavalent chromium
transcriptome
cell cycle
lncRNA
regulation network
Online Access:https://www.frontiersin.org/articles/10.3389/fgene.2020.597803/full

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