New Insights into Profibrotic Myofibroblast Formation in Systemic Sclerosis: When the Vascular Wall Becomes the Enemy

New Insights into Profibrotic Myofibroblast Formation in Systemic Sclerosis: When the Vascular Wall Becomes the Enemy

In systemic sclerosis (SSc), abnormalities in microvessel morphology occur early and evolve into a distinctive vasculopathy that relentlessly advances in parallel with the development of tissue fibrosis orchestrated by myofibroblasts in nearly all affected organs. Our knowledge of the cellular and m...

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Bibliographic Details
Main Authors: Eloisa Romano, Irene Rosa, Bianca Saveria Fioretto, Marco Matucci-Cerinic, Mirko Manetti
Format: Article
Language:English
Published: MDPI AG 2021-06-01
Series:Life
Subjects:
systemic sclerosis
fibrosis
myofibroblasts
endothelial-to-mesenchymal transition
pericytes
vascular smooth muscle cells
Online Access:https://www.mdpi.com/2075-1729/11/7/610

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