Generation of an ICF Syndrome Model by Efficient Genome Editing of Human Induced Pluripotent Stem Cells Using the CRISPR System

Generation of an ICF Syndrome Model by Efficient Genome Editing of Human Induced Pluripotent Stem Cells Using the CRISPR System

Genome manipulation of human induced pluripotent stem (iPS) cells is essential to achieve their full potential as tools for regenerative medicine. To date, however, gene targeting in human pluripotent stem cells (hPSCs) has proven to be extremely difficult. Recently, an efficient genome manipulation...

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Bibliographic Details
Main Authors: Izuho Hatada, Mika Kimura, Sumiyo Morita, Daiki Tamura, Takuro Horii
Format: Article
Language:English
Published: MDPI AG 2013-09-01
Series:International Journal of Molecular Sciences
Subjects:
CRISPR
iPS
Cas9
DNMT3B
ICF syndrome
genome engineering
Online Access:http://www.mdpi.com/1422-0067/14/10/19774

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