The Vitamin E Derivative Gamma Tocotrienol Promotes Anti-Tumor Effects in Acute Myeloid Leukemia Cell Lines

The Vitamin E Derivative Gamma Tocotrienol Promotes Anti-Tumor Effects in Acute Myeloid Leukemia Cell Lines

Acute myeloid leukemia (AML) is a blood cancer characterized by the formation of faulty defective myelogenous cells with morphological heterogeneity and cytogenic aberrations leading to a loss of their function. In an attempt to find an effective and safe AML treatment, vitamin E derivatives, includ...

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Main Authors: Paola Ghanem, Annalise Zouein, Maya Mohamad, Mohammad H. Hodroj, Tony Haykal, Sonia Abou Najem, Hassan Y. Naim, Sandra Rizk
Format: Article
Language:English
Published: MDPI AG 2019-11-01
Series:Nutrients
Subjects:
leukemia
vitamin e
gamma tocotrienols
apoptosis
Online Access:https://www.mdpi.com/2072-6643/11/11/2808
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spelling doaj-057892427a054c3c8c7f6a7d146af9942020-11-25T01:50:24ZengMDPI AGNutrients2072-66432019-11-011111280810.3390/nu11112808nu11112808The Vitamin E Derivative Gamma Tocotrienol Promotes Anti-Tumor Effects in Acute Myeloid Leukemia Cell LinesPaola Ghanem0Annalise Zouein1Maya Mohamad2Mohammad H. Hodroj3Tony Haykal4Sonia Abou Najem5Hassan Y. Naim6Sandra Rizk7Department of Natural Sciences, School of Arts and Science, Lebanese American University, Beirut 1102-2801, LebanonDepartment of Natural Sciences, School of Arts and Science, Lebanese American University, Beirut 1102-2801, LebanonDepartment of Natural Sciences, School of Arts and Science, Lebanese American University, Beirut 1102-2801, LebanonDepartment of Natural Sciences, School of Arts and Science, Lebanese American University, Beirut 1102-2801, LebanonDepartment of Natural Sciences, School of Arts and Science, Lebanese American University, Beirut 1102-2801, LebanonDepartment of Natural Sciences, School of Arts and Science, Lebanese American University, Beirut 1102-2801, LebanonDepartment of Physiological Chemistry, University of Veterinary Medicine Hannover, 30559 Hannover, GermanyDepartment of Natural Sciences, School of Arts and Science, Lebanese American University, Beirut 1102-2801, LebanonAcute myeloid leukemia (AML) is a blood cancer characterized by the formation of faulty defective myelogenous cells with morphological heterogeneity and cytogenic aberrations leading to a loss of their function. In an attempt to find an effective and safe AML treatment, vitamin E derivatives, including tocopherols were considered as potential anti-tumor compounds. Recently, other isoforms of vitamin E, namely tocotrienols have been proposed as potential potent anti-cancerous agents, displaying promising therapeutic effects in different cancer types. In this study we evaluated the anti-cancerous effects of γ-tocotrienol, on AML cell lines in vitro. For this purpose, AML cell lines incubated with γ-tocotrienol were examined for their viability, cell cycle status, apoptotic cell death, DNA fragmentation, production of reactive oxygen species and expression of proapoptotic proteins. Our results showed that γ-tocotrienol exhibits time and dose-dependent anti-proliferative, pro-apoptotic and antioxidant effects on U937 and KG-1 cell lines, through the upregulation of proteins involved in the intrinsic apoptotic pathway.https://www.mdpi.com/2072-6643/11/11/2808leukemiavitamin egamma tocotrienolsapoptosis
collection DOAJ
language English
format Article
sources DOAJ
author Paola Ghanem
Annalise Zouein
Maya Mohamad
Mohammad H. Hodroj
Tony Haykal
Sonia Abou Najem
Hassan Y. Naim
Sandra Rizk
spellingShingle Paola Ghanem
Annalise Zouein
Maya Mohamad
Mohammad H. Hodroj
Tony Haykal
Sonia Abou Najem
Hassan Y. Naim
Sandra Rizk
The Vitamin E Derivative Gamma Tocotrienol Promotes Anti-Tumor Effects in Acute Myeloid Leukemia Cell Lines
Nutrients
leukemia
vitamin e
gamma tocotrienols
apoptosis
author_facet Paola Ghanem
Annalise Zouein
Maya Mohamad
Mohammad H. Hodroj
Tony Haykal
Sonia Abou Najem
Hassan Y. Naim
Sandra Rizk
author_sort Paola Ghanem
title The Vitamin E Derivative Gamma Tocotrienol Promotes Anti-Tumor Effects in Acute Myeloid Leukemia Cell Lines
title_short The Vitamin E Derivative Gamma Tocotrienol Promotes Anti-Tumor Effects in Acute Myeloid Leukemia Cell Lines
title_full The Vitamin E Derivative Gamma Tocotrienol Promotes Anti-Tumor Effects in Acute Myeloid Leukemia Cell Lines
title_fullStr The Vitamin E Derivative Gamma Tocotrienol Promotes Anti-Tumor Effects in Acute Myeloid Leukemia Cell Lines
title_full_unstemmed The Vitamin E Derivative Gamma Tocotrienol Promotes Anti-Tumor Effects in Acute Myeloid Leukemia Cell Lines
title_sort vitamin e derivative gamma tocotrienol promotes anti-tumor effects in acute myeloid leukemia cell lines
publisher MDPI AG
series Nutrients
issn 2072-6643
publishDate 2019-11-01
description Acute myeloid leukemia (AML) is a blood cancer characterized by the formation of faulty defective myelogenous cells with morphological heterogeneity and cytogenic aberrations leading to a loss of their function. In an attempt to find an effective and safe AML treatment, vitamin E derivatives, including tocopherols were considered as potential anti-tumor compounds. Recently, other isoforms of vitamin E, namely tocotrienols have been proposed as potential potent anti-cancerous agents, displaying promising therapeutic effects in different cancer types. In this study we evaluated the anti-cancerous effects of γ-tocotrienol, on AML cell lines in vitro. For this purpose, AML cell lines incubated with γ-tocotrienol were examined for their viability, cell cycle status, apoptotic cell death, DNA fragmentation, production of reactive oxygen species and expression of proapoptotic proteins. Our results showed that γ-tocotrienol exhibits time and dose-dependent anti-proliferative, pro-apoptotic and antioxidant effects on U937 and KG-1 cell lines, through the upregulation of proteins involved in the intrinsic apoptotic pathway.
topic leukemia
vitamin e
gamma tocotrienols
apoptosis
url https://www.mdpi.com/2072-6643/11/11/2808
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