Recombinant TgHSP70 Immunization Protects against Toxoplasma gondii Brain Cyst Formation by Enhancing Inducible Nitric Oxide Expression

Recombinant TgHSP70 Immunization Protects against Toxoplasma gondii Brain Cyst Formation by Enhancing Inducible Nitric Oxide Expression

Toxoplasma gondii is known to cause congenital infection in humans and animals and severe disease in immunocompromised individuals; consequently development of vaccines against the parasite is highly necessary. Under stress conditions, T. gondii expresses the highly immunogenic heat shock protein 70...

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Bibliographic Details
Main Authors: Neide M. Silva, Paulo Czarnewski, Ester C. B. Araújo, Mário C. Oliveira, Tiago W. P. Mineo
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-04-01
Series:Frontiers in Cellular and Infection Microbiology
Subjects:
immunization
rTgHSP70
alum
Toxoplasma gondii
toxoplasmosis
Online Access:http://journal.frontiersin.org/article/10.3389/fcimb.2017.00142/full

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