Incompatibility of the circadian protein BMAL1 and HNF4α in hepatocellular carcinoma

Hepatocyte nuclear factor 4 alpha (HNF4α) is regulated by different promoters to generate two isoforms, one of which functions as a tumor suppressor. Here, the authors reveal that induction of the alternative isoform in hepatocellular carcinoma inhibits the circadian clock by repressing BMAL1, and t...

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Main Authors:	Baharan Fekry, Aleix Ribas-Latre, Corrine Baumgartner, Jonathan R. Deans, Christopher Kwok, Pooja Patel, Loning Fu, Rebecca Berdeaux, Kai Sun, Mikhail G. Kolonin, Sidney H. Wang, Seung-Hee Yoo, Frances M. Sladek, Kristin Eckel-Mahan
Format:	Article
Language:	English
Published:	Nature Publishing Group 2018-10-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-018-06648-6

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spelling	doaj-056eef75c52b4174ad77b500303fd84c2021-05-11T09:35:08ZengNature Publishing GroupNature Communications2041-17232018-10-019111710.1038/s41467-018-06648-6Incompatibility of the circadian protein BMAL1 and HNF4α in hepatocellular carcinomaBaharan Fekry0Aleix Ribas-Latre1Corrine Baumgartner2Jonathan R. Deans3Christopher Kwok4Pooja Patel5Loning Fu6Rebecca Berdeaux7Kai Sun8Mikhail G. Kolonin9Sidney H. Wang10Seung-Hee Yoo11Frances M. Sladek12Kristin Eckel-Mahan13Institute of Molecular Medicine, McGovern Medical School at the University of Texas Health Science Center (UT Health)Institute of Molecular Medicine, McGovern Medical School at the University of Texas Health Science Center (UT Health)Institute of Molecular Medicine, McGovern Medical School at the University of Texas Health Science Center (UT Health)Department of Molecular, Cell and Systems Biology, University of California RiversideInstitute of Molecular Medicine, McGovern Medical School at the University of Texas Health Science Center (UT Health)Department of Pediatrics, Molecular and Cellular Biology, Children’s Nutrition Research Center, Baylor College of MedicineDepartment of Pediatrics, Molecular and Cellular Biology, Children’s Nutrition Research Center, Baylor College of MedicineInstitute of Molecular Medicine, McGovern Medical School at the University of Texas Health Science Center (UT Health)Institute of Molecular Medicine, McGovern Medical School at the University of Texas Health Science Center (UT Health)Institute of Molecular Medicine, McGovern Medical School at the University of Texas Health Science Center (UT Health)Institute of Molecular Medicine, McGovern Medical School at the University of Texas Health Science Center (UT Health)Department of Biochemistry and Molecular Biology, McGovern Medical School at the University of Texas Health Science Center (UT Health)Department of Molecular, Cell and Systems Biology, University of California RiversideInstitute of Molecular Medicine, McGovern Medical School at the University of Texas Health Science Center (UT Health)Hepatocyte nuclear factor 4 alpha (HNF4α) is regulated by different promoters to generate two isoforms, one of which functions as a tumor suppressor. Here, the authors reveal that induction of the alternative isoform in hepatocellular carcinoma inhibits the circadian clock by repressing BMAL1, and the reintroduction of BMAL1 prevents HCC tumor growth.https://doi.org/10.1038/s41467-018-06648-6
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Baharan Fekry Aleix Ribas-Latre Corrine Baumgartner Jonathan R. Deans Christopher Kwok Pooja Patel Loning Fu Rebecca Berdeaux Kai Sun Mikhail G. Kolonin Sidney H. Wang Seung-Hee Yoo Frances M. Sladek Kristin Eckel-Mahan
spellingShingle	Baharan Fekry Aleix Ribas-Latre Corrine Baumgartner Jonathan R. Deans Christopher Kwok Pooja Patel Loning Fu Rebecca Berdeaux Kai Sun Mikhail G. Kolonin Sidney H. Wang Seung-Hee Yoo Frances M. Sladek Kristin Eckel-Mahan Incompatibility of the circadian protein BMAL1 and HNF4α in hepatocellular carcinoma Nature Communications
author_facet	Baharan Fekry Aleix Ribas-Latre Corrine Baumgartner Jonathan R. Deans Christopher Kwok Pooja Patel Loning Fu Rebecca Berdeaux Kai Sun Mikhail G. Kolonin Sidney H. Wang Seung-Hee Yoo Frances M. Sladek Kristin Eckel-Mahan
author_sort	Baharan Fekry
title	Incompatibility of the circadian protein BMAL1 and HNF4α in hepatocellular carcinoma
title_short	Incompatibility of the circadian protein BMAL1 and HNF4α in hepatocellular carcinoma
title_full	Incompatibility of the circadian protein BMAL1 and HNF4α in hepatocellular carcinoma
title_fullStr	Incompatibility of the circadian protein BMAL1 and HNF4α in hepatocellular carcinoma
title_full_unstemmed	Incompatibility of the circadian protein BMAL1 and HNF4α in hepatocellular carcinoma
title_sort	incompatibility of the circadian protein bmal1 and hnf4α in hepatocellular carcinoma
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2018-10-01
description	Hepatocyte nuclear factor 4 alpha (HNF4α) is regulated by different promoters to generate two isoforms, one of which functions as a tumor suppressor. Here, the authors reveal that induction of the alternative isoform in hepatocellular carcinoma inhibits the circadian clock by repressing BMAL1, and the reintroduction of BMAL1 prevents HCC tumor growth.
url	https://doi.org/10.1038/s41467-018-06648-6
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Incompatibility of the circadian protein BMAL1 and HNF4α in hepatocellular carcinoma

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