Pyrin-only protein 2 limits inflammation but improves protection against bacteria

Pyrin-only protein 2 limits inflammation but improves protection against bacteria

Pyrin-only proteins (POPs) are primate-specific negative regulators of inflammasome activation. Here the authors generate transgenic mice expressing POP2 under the control of the human promoter, and show that POP2 is important for balancing antibacterial inflammatory responsesin vivo.

Bibliographic Details
Main Authors: Sivakumar Periasamy, Kristen A. Porter, Maninjay K. Atianand, Hongnga T. Le, Sarah Earley, Ellen B. Duffy, Matthew C. Haller, Heather Chin, Jonathan A. Harton
Format: Article
Language:English
Published: Nature Publishing Group 2017-06-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/ncomms15564
Description
Summary:Pyrin-only proteins (POPs) are primate-specific negative regulators of inflammasome activation. Here the authors generate transgenic mice expressing POP2 under the control of the human promoter, and show that POP2 is important for balancing antibacterial inflammatory responsesin vivo.
ISSN:2041-1723

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